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Substance Name: Elotuzumab [USAN:INN]
RN: 915296-00-3
UNII: 1351PE5UGS

Note

  • A humanized monoclonal antibody that selectively targets glycoproteins expressed on myeloma cells.

    NCI: A humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is highly expressed by multiple myeloma cells, but minimally expressed by normal cells. (NCI Thesaurus)

Molecular Formula

  • C6476-H9982-N1714O2-016-S42
 

Classification Code

  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Elotuzumab [USAN:INN]

Synonyms

  • BMS 901608
  • BMS-901608
  • Elotuzumab
  • Empliciti
  • HuLuc-63
  • HuLuc63
  • PDL-063
  • PDL063
  • UNII-1351PE5UGS

Systematic Names

  • Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 kappa-chain, dimer
  • Immunoglobulin G1, anti-(human SLAM family member 7 (CD2-like receptor activating cytotoxic cells, CD319 antigen)), humanized mouse monoclonal HuLuc63 gamma-1 heavy chain (222-214')-disulfide with humanized mouse monoclonal HuLuc63 kappa light chain (228-228'';231-231'')-bisdisulfide dimer

Registry Numbers

CAS Registry Number

  • 915296-00-3

FDA UNII

  • 1351PE5UGS

System Generated Number

  • 0915296003