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Substance Name: (+)-Tetrandrine
RN: 518-34-3
UNII: 29EX23D5AJ
InChIKey: WVTKBKWTSCPRNU-KYJUHHDHSA-N
Note
- A bisbenzylisoquinoline that exhibits antifibrogenic activity.
Molecular Formula
- C38-H42-N2-O6
Molecular Weight
- 622.7578
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Antimalarials
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Antiparasitic Agents
- Antiprotozoal Agents
- Antiviral (COVID-19)
- Antiviral Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Immunologic Factors
- Immunosuppressive Agents
- Membrane Transport Modulators
- Mutation Data
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Names and Synonyms
Results Name
- (+)-Tetrandrine
Name of Substance
- Tetrandrine
Synonyms
- (+)-Tetrandrine
- (S,S)-Tetrandrine
- 2-27-00-00889 (Beilstein Handbook Reference)
- BRN 0877811
- CCRIS 2705
- D-Tetrandrine
- Fanchinine
- Hanjisong
- NSC 77037
- Sinomenine A
- Tetrandrin
- UNII-29EX23D5AJ
Systematic Names
- Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-
- Tetrandrine
Registry Numbers
CAS Registry Number
- 518-34-3
FDA UNII
- 29EX23D5AJ
Other Registry Numbers
- 5990-67-0
- 607379-81-7
- 6490-80-8
- 916770-74-6
System Generated Number
- 0000518343
Structure Descriptors
InChI
InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1InChIKey
WVTKBKWTSCPRNU-KYJUHHDHSA-NSmiles
COc1ccc2C[C@@H]3N(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 40mg/kg (40mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 25, Pg. 610, 1994. |
| mouse | LD50 | intraperitoneal | 41300ug/kg (41.3mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher,Peop. Rep. China, 1994Vol. -, Pg. 216, 1994. |
| mouse | LD50 | intravenous | 37500ug/kg (37.5mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 39, 1990. | |
| rabbit | LDLo | intravenous | 15mg/kg (15mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 39, 1990. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 217.5 | deg C | EXP | |
| log P (octanol-water) | 7.990 | (none) | EST | |
| Atmospheric OH Rate Constant | 4.08E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.