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Substance Name: CEP 8983
RN: 917828-47-8
InChIKey: BWVHYDYUKQEFHG-UHFFFAOYSA-N

Note

  • Inhibits PAR polymerase-1 and PAR polymerase-2.

    NCI: PARP inhibitor CEP-9722 A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER) ... /NCI Thesaurus/

Molecular Weight

  • 306.3196
 
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Names and Synonyms

Name of Substance

  • CEP 8983

Synonym

  • CEP8983

Registry Numbers

CAS Registry Number

  • 917828-47-8

System Generated Number

  • 0917828478

Structure Descriptors

InChI

1S/C18H14N2O3/c1-23-11-7-3-6-10-13(11)14-15-12(17(21)20-18(15)22)8-4-2-5-9(8)16(14)19-10/h3,6-7,19H,2,4-5H2,1H3,(H,20,21,22)

InChIKey

BWVHYDYUKQEFHG-UHFFFAOYSA-N