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Substance Name: Evofosfamide [USAN:INN]
RN: 918633-87-1
UNII: 8A9RZ3HN8W
InChIKey: UGJWRPJDTDGERK-UHFFFAOYSA-N

Note

  • An hypoxia-activated prodrug of bromo-isophosphoramide mustard; an antineoplastic agent.

    NCI: A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. (NCI Thesaurus)

Molecular Formula

  • C9-H16-Br2-N5-O4-P

Molecular Weight

  • 449.0384
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Results Name

  • Evofosfamide [USAN:INN]

Name of Substance

  • Evofosfamide [USAN:INN]
  • TH 302

Synonyms

  • Evofosfamide
  • TH-302
  • UNII-8A9RZ3HN8W

Systematic Name

  • Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

Registry Numbers

CAS Registry Number

  • 918633-87-1

FDA UNII

  • 8A9RZ3HN8W

System Generated Number

  • 0918633871

Structure Descriptors

InChI

1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)

InChIKey

UGJWRPJDTDGERK-UHFFFAOYSA-N

Smiles

Cn1c(cnc1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr