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Substance Name: Tolonium chloride [INN]
RN: 92-31-9
UNII: 15XUH0X66N
InChIKey: HNONEKILPDHFOL-UHFFFAOYSA-M

Note

  • A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.

Molecular Formula

  • C15-H16-N3-S.Cl

Molecular Weight

  • 305.8314
 

Classification Codes

  • Coagulants
  • Coloring Agents
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Hemostatics
  • Heparin Antagonists
  • Human Data
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Tolonium chloride
  • Tolonium chloride [INN]

MeSH Heading

  • Tolonium chloride

Synonyms

  • 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride
  • Basic Blue 17
  • Blutene
  • Blutene chloride
  • C.I. 925
  • C.I. Basic Blue 17
  • CCRIS 4933
  • Chlorure de tolonium
  • Chlorure de tolonium [INN-French]
  • Cloruro de tolonio
  • Cloruro de tolonio [INN-Spanish]
  • Dimethyltoluthionine chloride
  • Dimethyltoluthionine chloride (VAN)
  • EINECS 202-146-2
  • F Klot
  • Gabilin
  • Klot
  • Menodin
  • Modr Toluidinova
  • Modr Toluidinova [Czech]
  • Modr Zasadita 17
  • Modr Zasadita 17 [Czech]
  • NSC 11225
  • Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
  • Schultz 1041
  • Schultz no. 1041
  • Tolazul
  • Toloni chloridum
  • Tolonii chloridum
  • Tolonii chloridum [INN-Latin]
  • Tolonium
  • Tolonium chloride
  • Toluidene Blue O Chloride
  • Toluidinblau
  • Toluidinblau [German]
  • Toluidine Blue
  • Toluidine Blue (phenothiazine dye)
  • Toluidine Blue O
  • Toluidine Blue OO
  • UNII-15XUH0X66N

Systematic Names

  • 3-Amino-7-dimethylamino-2-methylphenazathionium
  • C.I. Basic Blue 17
  • Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
  • Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)
  • Tolonium chloride

Registry Numbers

CAS Registry Number

  • 92-31-9

FDA UNII

  • 15XUH0X66N

Other Registry Numbers

  • 1335204-66-4
  • 1336-01-2
  • 1374634-69-1
  • 2043361-07-3
  • 21785-03-5
  • 24684-06-8
  • 93211-79-1

System Generated Number

  • 0000092319

Molecular Formulas

Molecular Formula

  • C15-H16-N3-S.Cl

Molecular Formula Fragments

  • C15-H16-N3-S
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C15H16N3S.ClH/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H/q+1;/p-1

InChIKey

HNONEKILPDHFOL-UHFFFAOYSA-M

Smiles

Cc1cc2c(cc1N)[s+]c3cc(ccc3n2)N(C)C.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
domestic animals - goat/sheep LD50 intravenous 10mg/kg (10mg/kg)   Veterinary and Human Toxicology. Vol. 38, Pg. 329, 1996.
man TDLo unreported 43mg/kg/6D (43mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: OTHER CHANGES
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 597, 1969.
mouse LD50 intravenous 27560ug/kg (27.56mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Stanford Medical Bulletin. Vol. 9, Pg. 96, 1951.
mouse LD50 unreported 28mg/kg (28mg/kg)   Journal of Medicinal Chemistry. Vol. 17, Pg. 902, 1974.
rabbit LD50 intravenous 13440ug/kg (13.44mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Stanford Medical Bulletin. Vol. 9, Pg. 96, 1951.
rat LD50 intraperitoneal 215mg/kg (215mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 204, Pg. 288, 1947.
rat LD50 intravenous 28930ug/kg (28.93mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Stanford Medical Bulletin. Vol. 9, Pg. 96, 1951.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.260 (none)   EST
Water Solubility 3.82E+04 mg/L   EXP
Atmospheric OH Rate Constant 2.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.