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Substance Name: Proflavine [INN]
RN: 92-62-6
UNII: CY3RNB3K4T
InChIKey: WDVSHHCDHLJJJR-UHFFFAOYSA-N

Note

  • Topical antiseptic used mainly in wound dressings.

Molecular Formula

  • C13-H11-N3

Molecular Weight

  • 209.251
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Proflavine
  • Proflavine [INN]

MeSH Heading

  • Proflavine

Synonyms

  • 2,8-Diaminoacridine (European)
  • 2,8-Diaminoacridinium
  • 3,6-Diaminoacridine
  • 3,6-Diaminoacridinium
  • 3,7-Diamino-5-azaanthracene
  • 5-22-11-00322 (Beilstein Handbook Reference)
  • AI3-52128
  • BRN 0166050
  • CCRIS 1244
  • EINECS 202-172-4
  • HSDB 7071
  • Isoflav base
  • Proflavin
  • Proflavina
  • Proflavina [INN-Spanish]
  • Proflavine
  • Proflavinum
  • Proflavinum [INN-Latin]
  • UNII-CY3RNB3K4T

Systematic Names

  • 3,6-Acridinediamine
  • Acridine, 3,6-diamino-
  • Proflavine

Superlist Name

  • Proflavin

Registry Numbers

CAS Registry Number

  • 92-62-6

FDA UNII

  • CY3RNB3K4T

System Generated Number

  • 0000092626

Structure Descriptors

InChI

1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2

InChIKey

WDVSHHCDHLJJJR-UHFFFAOYSA-N

Smiles

c12c(nc3cc(N)ccc3c1)cc(N)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 11111ug/kg (11.111mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Lancet. Vol. 196, Pg. 838, 1919.
mouse LD50 intraperitoneal 50mg/kg (50mg/kg)   Chemotherapy Vol. 16, Pg. 371, 1971.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Journal of Medicinal Chemistry. Vol. 18, Pg. 320, 1975.
mouse LD50 subcutaneous 140mg/kg (140mg/kg)   British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 285 deg C   EXP
pKa Dissociation Constant 8.06 (none) 20 EXP
log P (octanol-water) 1.83 (none)   EXP
Water Solubility 5.00E+05 mg/L 20 EXP
Vapor Pressure 8.94E-08 mm Hg 25 EST
Henry's Law Constant 8.39E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.00E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.