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Substance Name: Benzidine
RN: 92-87-5
UNII: 2X02101HVF
InChIKey: HFACYLZERDEVSX-UHFFFAOYSA-N

Molecular Formula

  • C12-H12-N2

Molecular Weight

  • 184.241
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • TSCA Flag S (Substance is Identified in a Final Significant New Use Rule)
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 26
  • 2011 CERCLA Priority List, Rank: 30
  • Known to be a Carcinogen
  • Overall Carcinogenic Evaluation: Group 1
  • Reportable Quantity (RQ) = 1 lb
  • TWA see 1910.1010
  • TWA: exposure by all routes should be carefully controlled to levels as low as possible, skin; Confirmed human carcinogen

Names and Synonyms

Name of Substance

  • Benzidine

Synonyms

  • (1,1'-Biphenyl)-4,4'-diamine
  • 4,4'-Bianiline
  • 4,4'-Biphenyldiamine
  • 4,4'-Biphenylenediamine
  • 4,4'-Diamino-1,1'-biphenyl
  • 4,4'-Diaminobiphenyl
  • 4,4'-Diaminodiphenyl
  • 4,4'-Diphenylenediamine
  • 4-13-00-00364 (Beilstein Handbook Reference)
  • AI3-00140
  • Benzidin
  • Benzidin [Czech]
  • Benzidina
  • Benzidina [Italian]
  • Benzidine
  • Benzidine base
  • Benzioine
  • Benzydyna
  • Benzydyna [Polish]
  • Biphenyl, 4,4'-diamino-
  • BRN 0742770
  • C.I. 37225
  • C.I. Azoic Diazo Component 112
  • CCRIS 71
  • CI 37225
  • CI Azoic diazo component 112
  • EINECS 202-199-1
  • Fast Corinth Base B
  • HSDB 948
  • NCI-C03361
  • NSC 146476
  • p,p'-Diaminobiphenyl
  • p,p'-Dianiline
  • p,p-Bianiline
  • p-Benzidine
  • p-Diaminodiphenyl
  • RCRA waste number U021
  • UNII-2X02101HVF

Systematic Names

  • (1,1'-Biphenyl)-4,4'-diamine
  • Benzidine

Superlist Names

  • (1,1'-Biphenyl)-4,4'-diamine
  • Benzidine
  • Benzidine (and its salts)
  • Benzidine [UN1885] [Poison]
  • RCRA waste no. U021
  • UN1885

Registry Numbers

CAS Registry Number

  • 92-87-5

FDA UNII

  • 2X02101HVF

Other Registry Numbers

  • 46310-07-0
  • 56481-94-8

Related Registry Numbers

  • 14414-68-7 (hydrochloride)
  • 21136-70-9 (sulfate)
  • 36341-27-2 (unspecified acetate)
  • 531-85-1 (di-hydrochloride)
  • 531-86-2 (monosulfate)

System Generated Number

  • 0000092875

Structure Descriptors

InChI

1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2

InChIKey

HFACYLZERDEVSX-UHFFFAOYSA-N

Smiles

c1(c2ccc(N)cc2)ccc(N)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 200mg/kg (200mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907.
mouse LD50 intraperitoneal 110mg/kg (110mg/kg)   Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse LD50 oral 214mg/kg (214mg/kg)   National Technical Information Service. Vol. PB214-270,
rabbit LDLo oral 200mg/kg (200mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907.
rat LD50 oral 309mg/kg (309mg/kg)   National Technical Information Service. Vol. PB214-270,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 120 deg C   EXP
Boiling Point 401 deg C   EXP
pKa Dissociation Constant 4.66 (none) 20 EXP
log P (octanol-water) 1.34 (none)   EXP
Water Solubility 322 mg/L 25 EXP
Vapor Pressure 8.98E-07 mm Hg 25 EST
Henry's Law Constant 5.17E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.54E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.