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Substance Name: Iodixanol [USAN:USP:INN:BAN]
RN: 92339-11-2
UNII: HW8W27HTXX
InChIKey: NBQNWMBBSKPBAY-UHFFFAOYSA-N

Note

  • Dimeric contrast media.

Classification Codes

  • Contrast Media
  • Diagnostic Aid (Radiopaque Medium)

Molecular Formula

  • C35-H44-I6-N6-O15

Molecular Weight

  • 1550.1596
 

Names and Synonyms

Name of Substance

  • Iodixanol
  • Iodixanol [USAN:USP:INN:BAN]

Synonyms

  • 1,3-Benzenedicarboxamide, 5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-
  • 2-5410-3A
  • 5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)
  • CCRIS 7567
  • EC 618-837-0
  • HSDB 8076
  • Iodixanol
  • Iodixanolum
  • Iodixanolum [Latin]
  • OptiPrep
  • UNII-HW8W27HTXX
  • Visipaque
  • Visipaque 270
  • Visipaque 320

Systematic Names

  • 1,3-Benzenedicarboxamide, 5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-
  • 5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 5,5'-((2-hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide);
  • Indixanol

Registry Numbers

CAS Registry Number

  • 92339-11-2

FDA UNII

  • HW8W27HTXX

System Generated Number

  • 0092339112

Structure Descriptors

InChI

1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62)

InChIKey

NBQNWMBBSKPBAY-UHFFFAOYSA-N

Smiles

CC(=O)N(CC(O)CN(C(=O)C)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c2c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c2I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 30512mg/kg (30512mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Acta Radiologica, Supplementum. Vol. 399, Pg. 69, 1995.
rat LD50 intravenous > 42757mg/kg (42757mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: HEMORRHAGE
Acta Radiologica, Supplementum. Vol. 399, Pg. 69, 1995.