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Substance Name: Canagliflozin [USAN:INN]
RN: 928672-86-0
UNII: 0SAC974Z85
InChIKey: VHOFTEAWFCUTOS-TUGBYPPCSA-N

Notes

  • A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.
  • Manufacturers Label: INVOKANA (canagliflozin) contains canagliflozin, an inhibitor of sodium-glucose co-transporter 2 (SGLT2), the transporter responsible for reabsorbing the majority of glucose filtered by the kidney.

Molecular Formula

  • C24-H25-F-O5-S.1/2H2-O

Molecular Weight

  • 907.0558
 

Classification Codes

  • Antidiabetic
  • Hypoglycemic Agents

Names and Synonyms

Name of Substance

  • Canagliflozin [USAN:INN]

MeSH Heading

  • Canagliflozin

Synonyms

  • (1S)-1,5-Anhydro-1-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-D-glucitol hemihydrate
  • (1S)-1,5-Anhydro-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-D- glucitol hemihydrate
  • Canagliflozin
  • Invokana
  • JNJ 28431754
  • JNJ-24831754-ZAE
  • JNJ-28431754
  • JNJ-28431754-AAA
  • TA 7284
  • TA-7284
  • UNII-0SAC974Z85

Systematic Name

  • D-Glucitol, 1,5-anhydro-1-C-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-, hydrate (2:1), (1S)-

Registry Numbers

CAS Registry Number

  • 928672-86-0

FDA UNII

  • 0SAC974Z85

System Generated Number

  • 0928672860

Molecular Formulas

Molecular Formula

  • C24-H25-F-O5-S.1/2H2-O

Molecular Formula Fragments

  • C24-H25-F-O5-S
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/2C24H25FO5S.H2O/c2*1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14;/h2*2-10,19,21-24,26-29H,11-12H2,1H3;1H2/t2*19-,21-,22+,23-,24+;/m11./s1

InChIKey

VHOFTEAWFCUTOS-TUGBYPPCSA-N