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Substance Name: GSK-461364
RN: 929095-18-1
UNII: 8QO27TK6Q4
InChIKey: ZHJGWYRLJUCMRT-QGZVFWFLSA-N

Notes

  • A Plk1 inhibitor.
  • An antineoplastic agent that inhibits polo-like kinase 1.

Molecular Formula

  • C27-H28-F3-N5-O2-S

Molecular Weight

  • 543.6112
 
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Names and Synonyms

Name of Substance

  • GSK-461364

Synonyms

  • 2-Thiophenecarboxamide, 5-(6-((4-methyl-1-piperazinyl)methyl)-1H-benzimidazol-1-yl)-3-((1R)-1-(2-(trifluoromethyl)phenyl)ethoxy)-
  • 5-(6-((4-Methylpiperazin-1-yl)methyl)-1H-benzimidazol-1-yl)-3-(((1R)-1-(2-(trifluoromethyl)phenyl)ethyl)oxy)thiophene-2-carboxamide
  • GSK 461364
  • GSK-461364
  • GSK-461364A
  • GSK461364
  • UNII-8QO27TK6Q4

Registry Numbers

CAS Registry Number

  • 929095-18-1

FDA UNII

  • 8QO27TK6Q4

Other Registry Number

  • 1000873-97-1

System Generated Number

  • 0929095181

Structure Descriptors

InChI

1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1

InChIKey

ZHJGWYRLJUCMRT-QGZVFWFLSA-N

Smiles

C[C@H](c1ccccc1C(F)(F)F)Oc2cc(sc2C(=O)N)n3cnc4c3cc(cc4)CN5CCN(CC5)C