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Substance Name: Gadoterate meglumine [USAN]
RN: 92943-93-6
UNII: L0ND3981AG
InChIKey: DVDZVTIDPZSKGB-BMWGJIJESA-N

Note

  • NCI: A gadolinium chelate paramagnetic contrast agent. When placed in a magnetic field, gadoterate meglumine produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because gadobenate dimeglumine is excreted in the bile, it may be used to visualize the biliary system using MRI. (NCI Thesaurus)

Molecular Formula

  • C16-H25-Gd-N4-O8.C7-H17-N-O5

Molecular Weight

  • 756.8805
 

Classification Codes

  • Contrast Media
  • Contrast Medium for MRI
  • Diagnostic Uses of Chemicals
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Names and Synonyms

Name of Substance

  • Gadoterate meglumine [USAN]

Synonyms

  • D-Glucitol, 1-deoxy-1-(methylamino)-, (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetato(4-)-kappan1,kappan4,kappan7,kappan10,kappao1,kappao4,kappao7,kappao10)gadolinate(1-) (1:1)
  • Dotarem
  • Gadolinium-DOTA meglumine
  • Gadoterate meglumine
  • Gd-DOTA meglumine
  • HSDB 8230
  • Magnescope
  • P 449
  • UNII-L0ND3981AG

Registry Numbers

CAS Registry Number

  • 92943-93-6

FDA UNII

  • L0ND3981AG

System Generated Number

  • 0092943936

Structure Descriptors

InChI

InChI=1S/C16H28N4O8.C7H17NO5.Gd/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26;1-8-2-4(10)6(12)7(13)5(11)3-9;/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28);4-13H,2-3H2,1H3;/q;;-1/t;4-,5+,6+,7+;/m.0./s1

InChIKey

DVDZVTIDPZSKGB-BMWGJIJESA-N

Smiles

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C1C[NH]23CC[NH]45CC[NH]67CC[NH]8(CC2)CC(=O)[O-][Gd+3]3468([O-]C(=O)C7)([O-]C(=O)C5)[O-]1