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Substance Name: Of 4949-II
RN: 93375-50-9
InChIKey: BIINTWLXGRHBOS-UHFFFAOYSA-N

Note

  • Inhibitor of aminopeptidase B; produced by fungus Penicillium rugulosum OF4949.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H24-N4-O8

Molecular Weight

  • 472.452
 
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Names and Synonyms

Name of Substance

  • Of 4949-II

Synonym

  • Of 4949II

Systematic Name

  • 2-Oxa-11,14-diazatricyclo(15.2.2.1(sup 3,7))docosa-3,5,7(22),17,19,20-hexaene-15-carboxylic acid, 9-amino-12-(2-amino-1-hydroxy-2-oxoethyl)-10,13-dioxo-4-hydroxy-, (9S-(9R*,12R*(S*),15R*))-

Registry Numbers

CAS Registry Number

  • 93375-50-9

System Generated Number

  • 0093375509

Structure Descriptors

InChI

1S/C22H24N4O8/c23-13-7-11-3-6-15(27)16(9-11)34-12-4-1-10(2-5-12)8-14(22(32)33)25-21(31)17(26-20(13)30)18(28)19(24)29/h1-6,9,13-14,17-18,27-28H,7-8,23H2,(H2,24,29)(H,25,31)(H,26,30)(H,32,33)

InChIKey

BIINTWLXGRHBOS-UHFFFAOYSA-N

Smiles

N1C([C@@H](NC([C@@H](Cc2cc(Oc3ccc(C[C@@H]1C(O)=O)cc3)c(cc2)O)N)=O)[C@@H](C(N)=O)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 300mg/kg (300mg/kg)   Journal of Antibiotics. Vol. 39, Pg. 1674, 1986.