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Substance Name: OnabotulinumtoxinA [USAN]
RN: 93384-43-1
UNII: E211KPY694

Notes

  • A 150 kDa neurotoxic protein produced by CLOSTRIDIUM BOTULINUM. When consumed in contaminated food it can cause paralysis and death. In its purified form, it has been used in the treatment of BLEPHAROSPASM and STRABISMUS.
  • A type A botulinum toxin preparation.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Acetylcholine Release Inhibitors
  • Cholinergic Agents
  • Membrane Transport Modulators
  • Natural Product
  • Neuromuscular Agents
  • Neurotoxins
  • Neurotransmitter Agents
  • Noxae
  • Peripheral Nervous System Agents
  • Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia; Reduction of Glabellar Rhytides
  • Treatment of Cervical Dystonia, Severe Primary Axillary Hyperhidrosis, Glabellar Lines, Blepharospasm, Strabismus
  • Treatment of Glabellar Lines
  • Treatment of Spasticity, Cervical Dystonia, Benign Essential Blepharospasm and Glabellar Lines

Names and Synonyms

Results Name

  • OnabotulinumtoxinA [USAN]

Name of Substance

  • Abobotulinumtoxina [USAN]
  • Botulinum toxin type A
  • Botulinum toxins
  • Evabotulinumtoxina [USAN]
  • Incobotulinumtoxina [USAN]
  • OnabotulinumtoxinA [USAN]
  • Prabotulinumtoxin A [USAN]

MeSH Heading

  • Botulinum toxin type A

Synonyms

  • Abobotulinumtoxin A
  • AbobotulinumtoxinA
  • AGN 191622
  • Allergan (toxin)
  • Azzalure
  • Bocouture
  • Botox
  • Botox Cosmetic
  • Botulin A
  • Botulin toxin A
  • Botulinum A neurotoxin
  • Botulinum neurotoxin A
  • Botulinum neurotoxin type A (EC 3.4.24.69) from clostridium botulinum
  • Botulinum toxin type A
  • CNT 52120
  • DWP450
  • Dysport
  • EINECS 297-253-4
  • Evabotulinumtoxina
  • GSK 1358820
  • HSDB 7796
  • IncobotulinumtoxinA
  • Medytoxin
  • Neuronox
  • Neurotoxin, Botulinum A
  • NT 201
  • NT 201 toxin
  • Oculinum
  • Onabotulinum toxin type-A
  • OnabotulinumtoxinA
  • Onaclostox
  • Prabotulinumtoxin A
  • Toxine botulinique A
  • Toxine botulinique A [French]
  • UNII-E211KPY694
  • Vistabel
  • Xeomin

Systematic Names

  • Botulin A
  • Botulinum toxin A
  • Toxins, botulin, A

Registry Numbers

CAS Registry Number

  • 93384-43-1

FDA UNII

  • E211KPY694

System Generated Number

  • 0093384431

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD intramuscular > 24units/kg (24units/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR

MUSCULOSKELETAL: OTHER CHANGES
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
mouse LD50 intraperitoneal 160ng/kg (0.00016mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
mouse LD50 subcutaneous 4ng/kg (0.000004mg/kg)   Toxicon. Vol. 24, Pg. 1065, 1986.
mouse LD50 unreported 30pg/kg (0.00000003mg/kg)   Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980.
rat LD50 intramuscular 96units/kg (96units/kg) MUSCULOSKELETAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
rat LD50 intravenous 50units/kg (50units/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 655, 1997.
rat LDLo subcutaneous 1250mg/kg (1250mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Journal of Physiology. Vol. 260, Pg. 177, 1976.
women TDLo intramuscular 24iu/kg/2W-I (24iu/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Neurology, Neurosurgery and Psychiatry. Vol. 56, Pg. 220, 1993.