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Substance Name: Pilaralisib [USAN:INN]
RN: 934526-89-3
UNII: 60ES45KTMK
InChIKey: QINPEPAQOBZPOF-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors. (NCI Thesaurus)

Molecular Formula

  • C25-H25-Cl-N6-O4-S

Molecular Weight

  • 541.0295
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Pilaralisib [USAN:INN]
  • XL-147

Synonyms

  • 2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide
  • Pilaralisib
  • SAR-245408
  • SAR245408
  • UNII-60ES45KTMK
  • XL 147
  • XL147

Registry Numbers

CAS Registry Number

  • 934526-89-3

FDA UNII

  • 60ES45KTMK

System Generated Number

  • 0934526893

Structure Descriptors

InChI

1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32)

InChIKey

QINPEPAQOBZPOF-UHFFFAOYSA-N

Smiles

CC(C)(C(=O)Nc1cccc(c1)S(=O)(=O)Nc2c(nc3ccccc3n2)Nc4cc(ccc4Cl)OC)N