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Substance Name: Cobimetinib [USAN:INN]
RN: 934660-93-2
UNII: ER29L26N1X
InChIKey: BSMCAPRUBJMWDF-KRWDZBQOSA-N

Notes

  • Has antineoplastic activity.
  • Has antineoplastic activity.

    NCI: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases. (NCI Thesaurus)
  • NCI: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases. (NCI Thesaurus)

Molecular Formula

  • C21-H21-F3-I-N3-O2

Molecular Weight

  • 531.3099
 

Classification Code

  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Cobimetinib [USAN:INN]
  • XL518

Synonyms

  • (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone
  • Cobimetinib
  • Cotellic
  • GDC 0973
  • GDC-0973
  • Methanone, (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-((2S)-2-piperidinyl)-1-azetidinyl)-
  • RG 7420
  • UNII-ER29L26N1X
  • Xl 518
  • Xl-518

Registry Numbers

CAS Registry Number

  • 934660-93-2

FDA UNII

  • ER29L26N1X

Other Registry Number

  • 1029872-29-4

System Generated Number

  • 0934660932

Structure Descriptors

InChI

InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1

InChIKey

BSMCAPRUBJMWDF-KRWDZBQOSA-N

Smiles

OC1(CN(C1)C(=O)c2ccc(F)c(F)c2Nc3ccc(I)cc3F)[C@@H]4CCCCN4