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Substance Name: Cobimetinib [USAN:INN]
RN: 934660-93-2
UNII: ER29L26N1X
InChIKey: BSMCAPRUBJMWDF-KRWDZBQOSA-N
Notes
- Has antineoplastic activity.
- Has antineoplastic activity.
NCI: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases. (NCI Thesaurus) - NCI: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases. (NCI Thesaurus)
Molecular Formula
- C21-H21-F3-I-N3-O2
Molecular Weight
- 531.3099
Classification Code
- Antineoplastic Agents
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Names and Synonyms
Name of Substance
- Cobimetinib [USAN:INN]
- XL518
Synonyms
- (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone
- Cobimetinib
- Cotellic
- GDC 0973
- GDC-0973
- Methanone, (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-((2S)-2-piperidinyl)-1-azetidinyl)-
- RG 7420
- UNII-ER29L26N1X
- Xl 518
- Xl-518
Registry Numbers
CAS Registry Number
- 934660-93-2
FDA UNII
- ER29L26N1X
Other Registry Number
- 1029872-29-4
System Generated Number
- 0934660932