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Substance Name: Glimepiride [USAN:USP:INN:BAN]
RN: 93479-97-1
UNII: 6KY687524K
InChIKey: WIGIZIANZCJQQY-RUCARUNLSA-N

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Hypoglycemic
  • Hypoglycemic Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Reproductive Effect

Molecular Formula

  • C24-H34-N4-O5-S

Molecular Weight

  • 490.6216
 

Names and Synonyms

Name of Substance

  • Glimepiride
  • Glimepiride [USAN:USP:INN:BAN]

Synonyms

  • 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea
  • 1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-
  • Amarel
  • Amaryl
  • BRN 5365754
  • CCRIS 7083
  • Endial
  • Glemax
  • Glimepirid
  • Glimepirida
  • Glimepirida [Spanish]
  • Glimepiride
  • Glimepiridum
  • Glimepiridum [Latin]
  • Glorion
  • HOE 490
  • HOE490
  • UNII-6KY687524K

Systematic Names

  • 1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-
  • 1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-
  • Glimepiride

Mixture Names

  • Avandaryl
  • Duetact

Registry Numbers

CAS Registry Number

  • 93479-97-1

FDA UNII

  • 6KY687524K

System Generated Number

  • 0093479971

Structure Descriptors

InChI

1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-

InChIKey

WIGIZIANZCJQQY-RUCARUNLSA-N

Smiles

C1C(C)=C(CC)C(=O)N1C(NCCc1ccc(S(NC(N[C@@H]2CC[C@H](CC2)C)=O)(=O)=O)cc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 28ug/kg/2D-I (0.028mg/kg) BLOOD: HEMORRHAGE

BLOOD: THROMBOCYTOPENIA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Pharmacotherpy. Vol. 34, Pg. 120, 2000.
mouse LD50 unreported > 10gm/kg (10000mg/kg)   Diabetes Frontier. Vol. 3, Pg. 565, 1992.
rat LD intraperitoneal > 3950mg/kg (3950mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD oral > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD50 unreported > 10gm/kg (10000mg/kg)   Diabetes Frontier. Vol. 3, Pg. 565, 1992.