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Substance Name: Oprozomib [USAN:INN]
RN: 935888-69-0
UNII: MZ37792Y8J
InChIKey: SWZXEVABPLUDIO-WSZYKNRRSA-N

Note

  • Antineoplastic; an orally active proteasome inhibitor.

    NCI: An orally bioavailable proteasome inhibitor with potential antineoplastic activity. Oprozomib inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated. (NCI Thesaurus)

Molecular Formula

  • C25-H32-N4-O7-S

Molecular Weight

  • 532.6148
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Oprozomib [USAN:INN]

Synonyms

  • O-Methyl-N-((2-methylthiazol-5-yl)carbonyl)-L-seryl-O-methyl-N-((1S)-1-benzyl-2-((2R)- 2-methyloxiran-2-yl)-2-oxoethyl)-L-serinamide
  • ONX 0912
  • ONX-0912
  • Oprozomib
  • PR 047
  • UNII-MZ37792Y8J

Systematic Name

  • L-Serinamide, O-methyl-N-((2-methyl-5-thiazolyl)carbonyl)-L-seryl-O-methyl-N-((1S)-2- ((2R)-2-methyl-2-oxiranyl)-2-oxo-1-(phenylmethyl)ethyl)-

Registry Numbers

CAS Registry Number

  • 935888-69-0

FDA UNII

  • MZ37792Y8J

Other Registry Number

  • 1227167-05-6

System Generated Number

  • 0935888690

Structure Descriptors

InChI

1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1

InChIKey

SWZXEVABPLUDIO-WSZYKNRRSA-N

Smiles

COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]3(C)CO3