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Substance Name: Amosulalol hydrochloride [JAN]
RN: 93633-92-2
InChIKey: JRVCPDVOFCWKAG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H24-N2-O5-S.Cl-H

Molecular Weight

  • 416.923
 
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Names and Synonyms

Name of Substance

  • Amosulalol hydrochloride [JAN]
  • Amosulalol monohydrochloride

Synonyms

  • (+-)-5-Hydroxy-2-(2-(2-methoxyphenoxy)ethylamino)ethyl)-2-methylbenzolsulfonamid hydrochlorid
  • Amosulalol HCl
  • Amosulalol hydrochloride

Systematic Name

  • Benzenesulfonamide, 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, hydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 93633-92-2

System Generated Number

  • 0093633922

Molecular Formulas

Molecular Formula

  • C18-H24-N2-O5-S.Cl-H

Molecular Formula Fragments

  • C18-H24-N2-O5-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H24N2O5S.ClH/c1-13-7-8-14(11-18(13)26(19,22)23)15(21)12-20-9-10-25-17-6-4-3-5-16(17)24-2;/h3-8,11,15,20-21H,9-10,12H2,1-2H3,(H2,19,22,23);1H

InChIKey

JRVCPDVOFCWKAG-UHFFFAOYSA-N

Smiles

c1ccc(c(OC)c1)OCCNC[C@@H](c1cc(c(cc1)C)S(N)(=O)=O)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 104mg/kg (104mg/kg)   Drugs in Japan Vol. -, Pg. 62, 1990.
mouse LD50 intravenous 104mg/kg (104mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.
mouse LD50 oral 5740mg/kg (5740mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.
mouse LD50 subcutaneous 394mg/kg (394mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.
rat LD50 intraperitoneal > 104mg/kg (104mg/kg)   Drugs in Japan Vol. -, Pg. 62, 1990.
rat LD50 intravenous 105mg/kg (105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.
rat LD50 oral > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.
rat LD50 subcutaneous 541mg/kg (541mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6121, 1985.