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Substance Name: Tucatinib [USAN:INN]
RN: 937263-43-9
UNII: 234248D0HH
InChIKey: SDEAXTCZPQIFQM-UHFFFAOYSA-N

Notes

  • NCI: An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. (NCI Thesaurus)
  • Receptor tyrosine kinase inhibitor for tratment of HER2 positive breast cancer.

Molecular Formula

  • C26-H24-N8-O2

Molecular Weight

  • 480.5296
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
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Names and Synonyms

Name of Substance

  • Tucatinib
  • Tucatinib [USAN:INN]

Synonyms

  • 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)-
  • ARRY 380
  • ARRY-380
  • Irbinitinib
  • N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine
  • N6-(4,5-dihydro-4,4-dmethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-A)pyridin-7-Yloxy)phenyl)-4,6-quinazolinediamine
  • ONT 380
  • ONT-380
  • Tucatinib
  • Tukysa
  • UNII-234248D0HH

Registry Numbers

CAS Registry Number

  • 937263-43-9

FDA UNII

  • 234248D0HH

System Generated Number

  • 0937263439

Structure Descriptors

InChI

InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

InChIKey

SDEAXTCZPQIFQM-UHFFFAOYSA-N

Smiles

Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc5ccn6ncnc6c5