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Substance Name: 2,4-D [BSI:ISO]
RN: 94-75-7
UNII: 2577AQ9262
InChIKey: OVSKIKFHRZPJSS-UHFFFAOYSA-N

Note

  • An herbicide with irritant effects on the eye and the gastrointestinal system.

Molecular Formula

  • C8-H6-Cl2-O3

Molecular Weight

  • 221.0384
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Growth Regulator / Fertilizer
  • Herbicide
  • Herbicides
  • Human Data
  • Mutation Data
  • Pesticides
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 248
  • 2011 CERCLA Priority List, Rank: 243
  • Reportable Quantity (RQ) = 100 lb
  • TWA 10 mg/m3
  • TWA 10 mg/m3; Not classifiable as a human carcinogen

Names and Synonyms

Results Name

  • 2,4-D [BSI:ISO]

Name of Substance

  • 2,4-D
  • 2,4-D [BSI:ISO]
  • 2,4-Dichlorophenoxyacetic acid

MeSH Heading

  • 2,4-Dichlorophenoxyacetic acid

Synonyms

  • (2,4-Dichloor-fenoxy)-azijnzuur
  • (2,4-Dichloor-fenoxy)-azijnzuur [Dutch]
  • (2,4-Dichlor-phenoxy)-essigsaeure
  • (2,4-Dichlor-phenoxy)-essigsaeure [German]
  • (2,4-Dichlorophenyloxy)acetic acid
  • 2,4-D
  • 2,4-D acid
  • 2,4-Dichlorophenoxyacetic acid
  • 2,4-Dwuchlorofenoksyoctowy kwas
  • 2,4-Dwuchlorofenoksyoctowy kwas [Polish]
  • 2,4-PA
  • 4-06-00-00908 (Beilstein Handbook Reference)
  • Acetic acid, (2,4-dichlorophenoxy)-
  • Acide 2,4-dichloro phenoxyacetique
  • Acide 2,4-dichloro phenoxyacetique [French]
  • Acido(2,4-dicloro-fenossi)-acetico
  • Acido(2,4-dicloro-fenossi)-acetico [Italian]
  • Acme LV 4
  • Acme LV 6
  • Agricorn D
  • Agrotect
  • AI3-08538
  • Amoxone
  • B-Selektonon
  • Barrage
  • BH 2,4-D
  • BRN 1214242
  • Brush-rhap
  • Butoxy-D 3: 1 Liquid emulsifiable Brushkiller LV96
  • Butoxy-D 3: 1 Liquid emulsifiable Brushkiller LV96 [Canada]
  • Caswell No. 315
  • CCRIS 949
  • Chipco turf herbicide D
  • Chloroxone
  • Citrus fix
  • Crop rider
  • Croprider
  • De-Pester Ded-Weed LV-2
  • Debroussaillant 600
  • Ded-Weed LV-69
  • Deherban
  • Dichlorophenoxyacetic acid
  • Dicopur
  • Dormon
  • Dormone
  • EINECS 202-361-1
  • Emulsamine
  • Emulsamine BK
  • Emulsamine E-3
  • ENT 8,538
  • Envert DT
  • EPA Pesticide Chemical Code 030001
  • Esteron 44 weed killer
  • Esteron 76 BE
  • Estone
  • Fernesta
  • Fernimine
  • Ferxone
  • Foredex 75
  • Green Cross Weed-No-More 80
  • Hedonal
  • Hedonal (the herbicide)
  • Herbidal
  • Hivol-44
  • HSDB 202
  • Ipaner
  • Kwas 2,4-dwuchlorofenoksyoctowy
  • Kwas 2,4-dwuchlorofenoksyoctowy [Polish]
  • Kwasu 2,4-dwuchlorofenoksyoctowego
  • Kwasu 2,4-dwuchlorofenoksyoctowego [Polish]
  • Kyselina 2,4-dichlorfenoxyoctova
  • Kyselina 2,4-dichlorfenoxyoctova [Czech]
  • Lawn-keep
  • Macondray
  • Macrondray
  • Miracle
  • Mota Maskros
  • Moxon
  • Moxone
  • Netagrone
  • Netagrone 600
  • NSC 2925
  • Pennamine D
  • Phenox
  • Phenoxyacetic acid, 2,4-dichloro-
  • Pielik
  • Planotox
  • Plantgard
  • R-H Weed Rhap 20
  • RCRA waste number U240
  • Red Devil Dry Weed Killer
  • Rhodia
  • Scott's 4-XD Weed Control
  • Silvaprop 1
  • Superormone concentre
  • Tributon
  • U 46DP
  • U-5043
  • UNII-2577AQ9262
  • Vergemaster
  • Verton 2D
  • Verton 38
  • Vidon 638
  • Visko-rhap low drift herbicides
  • Visko-rhap low volatile 4l
  • Weed TOX
  • Weed-Ag-Bar
  • Weed-B-gon
  • Weed-rhap
  • Weed-Rhap A-4
  • Weed-Rhap B-266
  • Weed-Rhap B-4
  • Weed-Rhap I-3.34
  • Weed-Rhap LV-4-0
  • Weedatul
  • Weedez Wonder BAR
  • Weedone
  • Weedone 100 Emulsifiable
  • Weedone 100 Emulsifiable [Canada]
  • Weedone LV4
  • Weedtrol

Systematic Names

  • 2,4-D
  • 2,4-Dichlorophenoxyacetic acid
  • Acetic acid, (2,4-dichlorophenoxy)-
  • Acetic acid, 2-(2,4-dichlorophenoxy)-

Superlist Names

  • (2,4-Dichlorophenoxy)acetic acid
  • 2,4-D
  • 2,4-D acid
  • 2,4-D [Chlorophenoxy herbicides]
  • 2,4-D, salts and esters
  • 2,4-Dichlorophenoxyacetic acid
  • Acetic acid, (2,4-dichlorophenoxy)-
  • Acetic acid, (2,4-dichlorophenoxy)-, salts and esters
  • Dichlorophenoxyacetic acid
  • RCRA waste no. U240

Registry Numbers

CAS Registry Number

  • 94-75-7

FDA UNII

  • 2577AQ9262

Other Registry Number

  • 15183-39-8

Related Registry Numbers

  • 14214-89-2 (potassium salt)
  • 2307-55-3 (ammonium salt)
  • 2702-72-9 (hydrochloride salt)
  • 3766-27-6 (lithium salt)

System Generated Number

  • 0000094757

Structure Descriptors

InChI

1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)

InChIKey

OVSKIKFHRZPJSS-UHFFFAOYSA-N

Smiles

c1cc(c(cc1Cl)Cl)OCC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 541mg/kg (541mg/kg) LIVER: FATTY LIVER DEGERATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: GASTRITIS		 American Journal of Veterinary Research. Vol. 15, Pg. 622, 1954.
dog LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: STIFFNESS		 Archives of Environmental Health. Vol. 7, Pg. 202, 1963.
guinea pig LD50 intraperitoneal 666mg/kg (666mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA		 Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 85, 1947.
guinea pig LD50 oral 469mg/kg (469mg/kg)   American Journal of Veterinary Research. Vol. 15, Pg. 622, 1954.
hamster LD50 oral 500mg/kg (500mg/kg)   Toxicology and Applied Pharmacology. Vol. 48, Pg. A192, 1979.
human LDLo oral 80mg/kg (80mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING		 Archives of Pathology. Vol. 94, Pg. 270, 1972.
mammal (species unspecified) LD50 oral 375mg/kg (375mg/kg)   Science. Vol. 165, Pg. 465, 1969.
man LDLo oral 93mg/kg (93mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Pharmacological Reviews. Vol. 14, Pg. 225, 1962.
man TDLo oral 2gm/kg (2000mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Archives of Toxicology. Vol. 66, Pg. 518, 1992.
man TDLo oral 5714mg/kg (5714mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: COMA

CARDIAC: CHANGE IN RATE		 Archives of Toxicology. Vol. 66, Pg. 518, 1992.
mouse LD50 oral 347mg/kg (347mg/kg)   Roczniki Panstwowego Zakladu Higieny. Vol. 31, Pg. 373, 1980.
mouse LDLo intraperitoneal 125mg/kg (125mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
rabbit LD50 intraperitoneal 400mg/kg (400mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE		 Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 85, 1947.
rabbit LD50 intravenous 400mg/kg (400mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE		 Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 85, 1947.
rabbit LD50 skin 1400mg/kg (1400mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE		 Quarterly Bulletin--Association of Food and Drug Officials of the United States. Vol. 16, Pg. 3, 1952.
rabbit LDLo oral 800mg/kg (800mg/kg)   Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 12, Pg. 26, 1951.
rat LD50 intraperitoneal 666mg/kg (666mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE		 Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 85, 1947.
rat LD50 oral 375mg/kg (375mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C174, 1991.
rat LD50 skin 1500mg/kg (1500mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 140.5 deg C   EXP
pKa Dissociation Constant 2.73 (none)   EXP
log P (octanol-water) 2.81 (none)   EXP
Water Solubility 677 mg/L 25 EXP
Vapor Pressure 8.25E-05 mm Hg 20 EXP
Henry's Law Constant 3.54E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.63E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.