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Substance Name: Suplatast tosilate [INN]
RN: 94055-76-2
UNII: C9J89787U1
InChIKey: RYVJQEZJUFRANT-UHFFFAOYSA-N

Note

  • Inhibits antigen-produced histamine release from mast cells; inhibits IgE antibody formation.

Molecular Formula

  • C16-H26-N-O4-S.C7-H7-O3-S

Molecular Weight

  • 499.6457
 

Classification Codes

  • Anti-Allergic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Suplatast tosilate
  • Suplatast tosilate [INN]
  • Suplatast tosylate

Synonyms

  • (+-)-(2-((p-(3-Ethoxy-2-hydroxypropoxy)phenyl)carbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate
  • (+-)-(2-(4-(3-Ethoxy-2-hydroxypropoxy)phenyl)carbamoyl)ethyldimethylsulfonium p-tosylate
  • CCRIS 6596
  • IPD-1151T
  • Suplatast tosilate
  • Suplatastum tosilas
  • Suplatastum tosilas [INN-Latin]
  • Tosilate de suplatast
  • Tosilate de suplatast [INN-French]
  • Tosilato de suplatast
  • Tosilato de suplatast [INN-Spanish]
  • UNII-C9J89787U1

Systematic Names

  • (+-)-(2-((p-(3-Ethoxy-2-hydroxypropoxy)phenyl)carbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate
  • Sulfonium, (3-((4-(3-ethoxy-2-hydroxypropoxy)phenyl)amino)-3-oxopropyl)dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)
  • Suplatast tosilate

Registry Numbers

CAS Registry Number

  • 94055-76-2

FDA UNII

  • C9J89787U1

System Generated Number

  • 0094055762

Molecular Formulas

Molecular Formula

  • C16-H26-N-O4-S.C7-H7-O3-S

Molecular Formula Fragments

  • C16-H26-N-O4-S
  • C7-H7-O3-S
  • COMPONENT

Structure Descriptors

InChI

1S/C16H25NO4S.C7H8O3S/c1-4-20-11-14(18)12-21-15-7-5-13(6-8-15)17-16(19)9-10-22(2)3;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,14,18H,4,9-12H2,1-3H3;2-5H,1H3,(H,8,9,10)

InChIKey

RYVJQEZJUFRANT-UHFFFAOYSA-N

Smiles

CCOCC(O)COc1ccc(NC(=O)CC[S+](C)C)cc1.Cc2ccc(cc2)S(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2124mg/kg (2124mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse LD50 intravenous 81mg/kg (81mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse LD50 oral > 12500mg/kg (12500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 intravenous 93mg/kg (93mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat LD50 oral > 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.