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Substance Name: Midesteine [INN]
RN: 94149-41-4
UNII: 90K2YE9FTO
InChIKey: MKTVMEMIKNBVHI-UHFFFAOYSA-N

Note

  • A cyclic thiolic neutrophil elastase inhibitor.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H13-N-O3-S3

Molecular Weight

  • 315.437
 
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Names and Synonyms

Name of Substance

  • Midesteine
  • Midesteine [INN]

Synonyms

  • 2-(Thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide
  • Midesteina
  • Midesteina [INN-Spanish]
  • Midesteine
  • Midesteinum
  • Midesteinum [INN-Latin]
  • MR 889
  • UNII-90K2YE9FTO

Systematic Names

  • 2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester
  • 2-Thiophenecarbothioic acid, S-ester with (+-)-2-mercapto-N-(tetrahydro-2-oxo-3-thienyl)propionamide

Registry Numbers

CAS Registry Number

  • 94149-41-4

FDA UNII

  • 90K2YE9FTO

System Generated Number

  • 0094149414

Structure Descriptors

InChI

1S/C12H13NO3S3/c1-7(19-12(16)9-3-2-5-17-9)10(14)13-8-4-6-18-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)

InChIKey

MKTVMEMIKNBVHI-UHFFFAOYSA-N

Smiles

s1cccc1C(S[C@@H](C(N[C@@H]1CCSC1=O)=O)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 15, Pg. 997, 1990.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 15, Pg. 997, 1990.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 15, Pg. 997, 1990.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 15, Pg. 997, 1990.