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Substance Name: Ruxolitinib [USAN:INN]
RN: 941678-49-5
UNII: 82S8X8XX8H
InChIKey: HFNKQEVNSGCOJV-OAHLLOKOSA-N

Note

  • NCI: /Ruxolitinib phosphate/ The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. (NCI Thesaurus)

Molecular Formula

  • C17-H18-N6

Molecular Weight

  • 306.3712
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Ruxolitinib [USAN:INN]

Synonyms

  • HSDB 8259
  • INC 424
  • INCB 018424
  • INCB018424
  • R-Ruxolitinib
  • Ruxolitinib
  • UNII-82S8X8XX8H

Systematic Name

  • 1H-Pyrazole-1-propanenitrile, beta-cyclopentyl-4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betaR)-

Registry Numbers

CAS Registry Number

  • 941678-49-5

FDA UNII

  • 82S8X8XX8H

Other Registry Number

  • 1138325-12-8

System Generated Number

  • 0941678495

Structure Descriptors

InChI

1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

InChIKey

HFNKQEVNSGCOJV-OAHLLOKOSA-N

Smiles

N#CC[C@H](C1CCCC1)n2cc(cn2)c3ncnc4[nH]ccc34