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Substance Name: Ponatinib [USAN:INN]
RN: 943319-70-8
UNII: 4340891KFS
InChIKey: PHXJVRSECIGDHY-UHFFFAOYSA-N

Note

  • A pan-Bcr-Abl protein kinase Inhibitor.

Molecular Formula

  • C29-H27-F3-N6-O

Molecular Weight

  • 532.5673
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Ponatinib
  • Ponatinib [USAN:INN]

Synonyms

  • 3-(2-(Imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1- yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
  • AP 24534
  • AP24534
  • HSDB 8184
  • Ponatinib
  • UNII-4340891KFS

Systematic Name

  • Benzamide, 3-(2-imidazo(1,2-b)pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methyl-1- piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-

Registry Numbers

CAS Registry Number

  • 943319-70-8

FDA UNII

  • 4340891KFS

System Generated Number

  • 0943319708

Structure Descriptors

InChI

1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)

InChIKey

PHXJVRSECIGDHY-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1C#Cc2cnc3n2nccc3)C(=O)Nc4ccc(c(c4)C(F)(F)F)CN5CCN(CC5)C