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Substance Name: Cromakalim [INN:BAN]
RN: 94470-67-4
UNII: 0G4X367WA3
InChIKey: TVZCRIROJQEVOT-CABCVRRESA-N

Note

  • A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)

Molecular Formula

  • C16-H18-N2-O3

Molecular Weight

  • 286.3292
 

Classification Codes

  • Anti-Asthmatic Agents
  • Antihypertensive Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Cardiovascular Agents
  • Parasympatholytics
  • Peripheral Nervous System Agents
  • Respiratory System Agents
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Cromakalim
  • Cromakalim [INN:BAN]

MeSH Heading

  • Cromakalim

Synonyms

  • BRL 34915
  • Cromakalim
  • Cromakalim, trans-Isomer
  • Cromakalime
  • Cromakalime [French]
  • Cromakalimum
  • Cromakalimum [Latin]
  • UNII-0G4X367WA3

Systematic Names

  • (+-)-trans-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile
  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-

Registry Numbers

CAS Registry Number

  • 94470-67-4

FDA UNII

  • 0G4X367WA3

System Generated Number

  • 0094470674

Structure Descriptors

InChI

1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

InChIKey

TVZCRIROJQEVOT-CABCVRRESA-N

Smiles

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N