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Substance Name: Levcromakalim [USAN:INN:BAN]
RN: 94535-50-9
UNII: RW7PN4BLDJ
InChIKey: TVZCRIROJQEVOT-CABCVRRESA-N
Classification Codes
- Anti-Asthmatic
- Antihypertensive
- Drug / Therapeutic Agent
- Potassium-ATP Channel Opener
Molecular Formula
- C16-H18-N2-O3
Molecular Weight
- 286.3292
- All
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
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Names and Synonyms
Name of Substance
- Levcromakalim [USAN:INN:BAN]
Synonyms
- (-)-Cromakalim
- (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile
- BRL 38227
- BRL-38227
- BRN 3622889
- Cromakalim, (3S-trans)-Isomer
- Lemakalim
- Levcromakalim
- UNII-RW7PN4BLDJ
Systematic Name
- 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-
Registry Numbers
CAS Registry Number
- 94535-50-9
FDA UNII
- RW7PN4BLDJ
System Generated Number
- 0094535509
Structure Descriptors
InChI
InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1InChIKey
TVZCRIROJQEVOT-CABCVRRESA-NSmiles
CC1(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD | intravenous | > 4mg/kg (4mg/kg) | BEHAVIORAL: COMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl, |
| mouse | LD | oral | > 750mg/kg (750mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl, |
| rat | LD | intravenous | > 4mg/kg (4mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl, |
| rat | LD | oral | > 2500mg/kg (2500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl, |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 2.1 | (none) | EXP | |
| Water Solubility | 274 | mg/L | 25 | EST |
| Vapor Pressure | 8.45E-10 | mm Hg | 25 | EST |
| Henry's Law Constant | 6.27E-15 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 9.34E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.