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Substance Name: Levcromakalim [USAN:INN:BAN]
RN: 94535-50-9
UNII: RW7PN4BLDJ
InChIKey: TVZCRIROJQEVOT-CABCVRRESA-N

Classification Codes

  • Anti-Asthmatic
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Potassium-ATP Channel Opener

Molecular Formula

  • C16-H18-N2-O3

Molecular Weight

  • 286.3292
 
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Names and Synonyms

Name of Substance

  • Levcromakalim [USAN:INN:BAN]

Synonyms

  • (-)-Cromakalim
  • (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile
  • BRL 38227
  • BRL-38227
  • BRN 3622889
  • Cromakalim, (3S-trans)-Isomer
  • Lemakalim
  • Levcromakalim
  • UNII-RW7PN4BLDJ

Systematic Name

  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-

Registry Numbers

CAS Registry Number

  • 94535-50-9

FDA UNII

  • RW7PN4BLDJ

System Generated Number

  • 0094535509

Structure Descriptors

InChI

InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

InChIKey

TVZCRIROJQEVOT-CABCVRRESA-N

Smiles

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 4mg/kg (4mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
mouse LD oral > 750mg/kg (750mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
rat LD intravenous > 4mg/kg (4mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
rat LD oral > 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.1 (none)   EXP
Water Solubility 274 mg/L 25 EST
Vapor Pressure 8.45E-10 mm Hg 25 EST
Henry's Law Constant 6.27E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.34E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.