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Substance Name: Famitinib
RN: 945380-27-8
InChIKey: GKEYKDOLBLYGRB-LGMDPLHJSA-N

Note

  • NCI: An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Famitinib binds to and inhibits several RTKs, dysregulated in a variety of tumors, including stem cell factor receptor (c-Kit; SCFR), vascular endothelial growth factor receptor (VEGFR) 2 and 3, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinases Flt1 and Flt3. Inhibition of these RTKs may result in an inhibition of tumor growth and angiogenesis, and eventually tumor regression in tumor cells overexpressing these RTKs. (NCI Thesaurus)

Molecular Formula

  • C23-H27-F-N4-O2

Molecular Weight

  • 410.4903
 
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Names and Synonyms

Name of Substance

  • Famitinib

Synonyms

  • Famitinib
  • SHR-1020
  • SHR1020

Registry Numbers

CAS Registry Number

  • 945380-27-8

System Generated Number

  • 0945380278

Structure Descriptors

InChI

1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-

InChIKey

GKEYKDOLBLYGRB-LGMDPLHJSA-N

Smiles

CCN(CC)CCN1CCc2c(c(c([nH]2)/C=C\3/c4cc(ccc4NC3=O)F)C)C1=O