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Substance Name: Pexmetinib [INN]
RN: 945614-12-0
UNII: 3750D0U8B5
InChIKey: LNMRSSIMGCDUTP-UHFFFAOYSA-N

Note

  • Inhibits both p38 mitogen-activated protein kinase and Tie2 protein.

Molecular Formula

  • C31-H33-F-N6-O3

Molecular Weight

  • 556.6387
 
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Names and Synonyms

Name of Substance

  • Pexmetinib [INN]

Synonyms

  • ARRY-614
  • N-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)-N'-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea
  • Pexmetinib
  • UNII-3750D0U8B5
  • Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-((5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)phenyl)methyl)-

Registry Numbers

CAS Registry Number

  • 945614-12-0

FDA UNII

  • 3750D0U8B5

System Generated Number

  • 0945614120

Structure Descriptors

InChI

1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3,(H2,33,35,40)

InChIKey

LNMRSSIMGCDUTP-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)n2c(cc(n2)C(C)(C)C)NC(=O)NCc3cc(ccc3Oc4ccc5c(c4)cnn5CCO)F