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Substance Name: Volasertib trihydrochloride [USAN]
RN: 946161-17-7
UNII: O72812O5MN
InChIKey: JFEPFDDQDQBWIL-VCVQLDHKSA-N

Note

  • A polo-like kinase inhibitor with broad antitumor activity.

    NCI: A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. (NCI Thesaurus)

Molecular Formula

  • C34-H50-N8-O3.3(H-Cl)

Molecular Weight

  • 728.2047
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Volasertib trihydrochloride [USAN]

Synonyms

  • BI 6727 CL3
  • N-(Trans-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-4-(((7R)-7-ethyl-5-methyl-8- (1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide trihydrochloride
  • UNII-O72812O5MN
  • Volasertib trihydrochloride

Systematic Name

  • Benzamide, N-(trans-4-(4-(cyclopropylmethyl)-1-piperazinyl)cyclohexyl)-4-(((7R)-7- ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl)amino)-3- methoxy-, hydrochloride (1:3)

Registry Numbers

CAS Registry Number

  • 946161-17-7

FDA UNII

  • O72812O5MN

System Generated Number

  • 0946161177

Structure Descriptors

InChI

1S/C34H50N8O3.3ClH/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23;;;/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38);3*1H/t25-,26-,28-;;;/m1.../s1

InChIKey

JFEPFDDQDQBWIL-VCVQLDHKSA-N