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Substance Name: Nivolumab [USAN:INN]
RN: 946414-94-4
UNII: 31YO63LBSN

Notes

  • A genetically engineered, fully human immunoglobulin G4 (IgG4) monoclonal anti programmed death-1/PD-1 protein antibody.
  • A genetically engineered, fully human immunoglobulin G4 (IgG4) monoclonal anti programmed death-1/PD-1 protein antibody.

    NCI: A fully human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1/PCD-1) with immunopotentiation activity. Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands PD-L1 and PD-L2, resulting in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and effector function through the suppression of P13k/Akt pathway activation. (NCI Thesaurus)

Molecular Formulas

  • C6362-H9862-N1712-O1995-S42
  • Unspecified
 

Classification Code

  • Antineoplastic Agents

Names and Synonyms

Results Name

  • Nivolumab [USAN:INN]

Name of Substance

  • MDX-1106
  • Nivolumab
  • Nivolumab [USAN:INN]

Synonyms

  • Anti-PD-1 human monoclonal antibody MDX-1106.
  • BMS 936558
  • BMS-936558
  • HSDB 8256
  • MDX 1106
  • MDX-1106
  • Nivolumab
  • ONO 4538
  • ONO-4538
  • Opdivo
  • UNII-31YO63LBSN

Registry Numbers

CAS Registry Number

  • 946414-94-4

FDA UNII

  • 31YO63LBSN

System Generated Number

  • 0946414944