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Substance Name: Lemildipine [INN]
RN: 94739-29-4
UNII: R3BD0YW4ZF
InChIKey: WTOVRSWDBLIFHU-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C20-H22-Cl2-N2-O6

Molecular Weight

  • 457.3078
 
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Names and Synonyms

Name of Substance

  • Lemildipine [INN]
  • NPK 1886

Synonyms

  • 3-Isopropyl 5-methyl (+-)-4-(2,3-dichlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylate, carbamate (ester)
  • CCRIS 7339
  • Lemildipine
  • NB 818
  • NB-818
  • NPK-1886
  • UNII-R3BD0YW4ZF

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2-(hydroxymethyl)-6-methyl-,3-isopropyl 5-methyl ester, carbamate (ester)
  • 3,5-Pyridinedicarboxylic acid, 2-(((aminocarbonyl)oxy)methyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-, 5-methyl 3-(1-methylethyl) ester
  • Lemildipine

Registry Numbers

CAS Registry Number

  • 94739-29-4

FDA UNII

  • R3BD0YW4ZF

Other Registry Number

  • 125729-29-5

System Generated Number

  • 0094739294

Structure Descriptors

InChI

1S/C20H22Cl2N2O6/c1-9(2)30-19(26)16-13(8-29-20(23)27)24-10(3)14(18(25)28-4)15(16)11-6-5-7-12(21)17(11)22/h5-7,9,15,24H,8H2,1-4H3,(H2,23,27)

InChIKey

WTOVRSWDBLIFHU-UHFFFAOYSA-N

Smiles

COC(=O)C1=C(C)NC(=C(C1c2cccc(Cl)c2Cl)C(=O)OC(C)C)COC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
mouse LD50 intraperitoneal 246mg/kg (246mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
mouse LD50 intraperitoneal 246mg/kg (246mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
mouse LD50 intravenous 38mg/kg (38mg/kg)   Japanese Journal of Pharmacology. Vol. 40, Pg. 399, 1986.
mouse LD50 oral > 6gm/kg (6000mg/kg)   Japanese Journal of Pharmacology. Vol. 40, Pg. 399, 1986.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
rat LD50 intraperitoneal 293mg/kg (293mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
rat LD50 intraperitoneal 293mg/kg (293mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
rat LD50 intravenous 29700ug/kg (29.7mg/kg)   Japanese Journal of Pharmacology. Vol. 40, Pg. 399, 1986.
rat LD50 oral > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 50, Pg. 235, 1995.