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Substance Name: Ramucirumab [USAN:INN]
RN: 947687-13-0
UNII: D99YVK4L0X

Notes

  • A fully human monoclonal antibody developed to specifically inhibit VEGFR-2.
  • A fully human monoclonal antibody developed to specifically inhibit VEGFR-2.

    NCI: A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an in inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells. (NCI Thesaurus)

Molecular Formula

  • C6376-H9886-N1702-O1996-S46
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic, Treatment of Solid Tumors

Names and Synonyms

Name of Substance

  • Ramucirumab [USAN:INN]

Synonyms

  • 1121B
  • Cyramza
  • IMC 1121B
  • IMC-1121B
  • Immunoglobulin G1, anti-(human vascular endothelial growth factor receptor type VEGFR-2 extracellular domain) (human monoclonal IMC-1121B gamma-chain), disulfide with human monoclonal IMC-1121B kappa-chain, dimer
  • Ramucirumab
  • UNII-D99YVK4L0X

Systematic Name

  • Immunoglobulin G1, anti-(human vascular endothelial growth factor receptor 2 (fetal liver kinase 1, kinase insert domain receptor, protein-tyrosine kinase receptor Flk-1, CD309) extracellular domain); human monoclonal IMC-1121B (125-leucine(CH19- F>L))gamma1 heavy chain (219-214')-disulfide with human monoclonal IMC-1121B kappa light chain dimer (225-225'':228-228'')-bisdisulfide

Registry Numbers

CAS Registry Number

  • 947687-13-0

FDA UNII

  • D99YVK4L0X

System Generated Number

  • 0947687130