Substance Name: Ramucirumab [USAN:INN]
RN: 947687-13-0
UNII: D99YVK4L0X
Notes
- A fully human monoclonal antibody developed to specifically inhibit VEGFR-2.
- A fully human monoclonal antibody developed to specifically inhibit VEGFR-2.
NCI: A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an in inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells. (NCI Thesaurus)
Molecular Formula
- C6376-H9886-N1702-O1996-S46
Classification Codes
- Antineoplastic Agents
- Antineoplastic, Treatment of Solid Tumors
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Ramucirumab [USAN:INN]
Synonyms
- 1121B
- Cyramza
- HSDB 8314
- IMC 1121B
- IMC-1121B
- IMC1121B
- Immunoglobulin G1, anti-(human vascular endothelial growth factor receptor type VEGFR-2 extracellular domain) (human monoclonal IMC-1121B gamma-chain), disulfide with human monoclonal IMC-1121B kappa-chain, dimer
- LY3009806
- NSC 749128
- Ramucirumab
- UNII-D99YVK4L0X
Systematic Name
- Immunoglobulin G1, anti-(human vascular endothelial growth factor receptor 2 (fetal liver kinase 1, kinase insert domain receptor, protein-tyrosine kinase receptor Flk-1, CD309) extracellular domain); human monoclonal IMC-1121B (125-leucine(CH19- F>L))gamma1 heavy chain (219-214')-disulfide with human monoclonal IMC-1121B kappa light chain dimer (225-225'':228-228'')-bisdisulfide
Registry Numbers
CAS Registry Number
- 947687-13-0
FDA UNII
- D99YVK4L0X
System Generated Number
- 0947687130