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Substance Name: Ampicillin mixture with Sulbactam
RN: 94935-63-4
InChIKey: KMEGBUCIGMEPME-LQYKFRDPSA-N

Note

  • A combination of ampicillin & sulbactam used in the treatment of infectious complications & bronchopulmonary diseases; a Russian compound.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H19-N3-O4-S.C8-H11-N-O5-S

Molecular Weight

  • 581.6639
 

Names and Synonyms

Results Name

  • Ampicillin mixture with Sulbactam

Name of Substance

  • Sulacillin

Synonyms

  • Ampicillin and sulbactam
  • Ampicillin sodium and sulbactam sodium
  • Ampicillin-sulbactam
  • Ampicillin-sulbactam mixt.
  • Sulacillin
  • Sulbactam-Ampicillin mixt. (1:2)
  • Unasyn

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2R)-aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S,5R,6R)-, mixt. with (2S,5R)-3,3-dimethyl-7-oxo-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2-alpha,5-alpha,6-beta(S*)))-, mixt. with (2S-cis)-3,3-dimethyl-7-oxo-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide

Registry Numbers

CAS Registry Number

  • 94935-63-4

System Generated Number

  • 0094935634

Molecular Formulas

Molecular Formula

  • C16-H19-N3-O4-S.C8-H11-N-O5-S

Molecular Formula Fragments

  • C16-H19-N3-O4-S
  • C8-H11-N-O5-S
  • COMPONENT

Structure Descriptors

InChI

1S/C16H19N3O4S.C9H12O5S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;1-9(2)7(8(11)12)6-4(10)3-5(6)15(9,13)14/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);5-7H,3H2,1-2H3,(H,11,12)/t9-,10-,11+,14-;5-,6?,7+/m11/s1

InChIKey

KMEGBUCIGMEPME-LQYKFRDPSA-N

Smiles

CC1([C@@H](C2[C@H](S1(=O)=O)CC2=O)C(=O)O)C.CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c3ccccc3)N)C(=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
mouse LD50 oral > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS		 Chemotherapy Vol. 36(Suppl,
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
mouse LDLo intravenous 6095mg/kg (6095mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
rat LD50 intraperitoneal > 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
rat LD50 intravenous 6820mg/kg (6820mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
rat LD50 oral > 6gm/kg (6000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS		 Chemotherapy Vol. 36(Suppl,
rat LD50 subcutaneous > 6gm/kg (6000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,