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Substance Name: Chlorzoxazone [USP:INN:BAN:JAN]
RN: 95-25-0
UNII: H0DE420U8G
InChIKey: TZFWDZFKRBELIQ-UHFFFAOYSA-N
Note
- A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202).
Molecular Formula
- C7-H4-Cl-N-O2
Molecular Weight
- 169.5666
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Muscle Relaxants, Central
- Neuromuscular Agents
- Peripheral Nervous System Agents
- Relaxant (Skeletal Muscle)
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Names and Synonyms
Name of Substance
- Chlorzoxazone
- Chlorzoxazone [USP:INN:BAN:JAN]
MeSH Heading
- Chlorzoxazone
Synonyms
- 2-Hydroxy-5-chlorobenzoxazole
- 5-Chlorbenzoxazolin-2-on
- 5-Chloro-2-benzoxazolinone
- 5-Chloro-2-benzoxazolol
- 5-Chloro-2-hydroxybenzoxazole
- 5-Chloro-3(H)-2-benzoxazolone
- 5-Chlorobenzoksazolinon-2
- 5-Chlorobenzoksazolinon-2 [Polish]
- 5-Chlorobenzoksazolon-2
- 5-Chlorobenzoksazolon-2 [Polish]
- 5-Chlorobenzoxazol-2-one
- 5-Chlorobenzoxazolidone
- 5-Chlorobenzoxazolone
- 6-Chloro-2-benzoxazolinone
- AI3-63119
- Biomioran
- Chloroxazone
- Chlorsoxazone
- Chlorzoxazon
- Chlorzoxazone
- Chlorzoxazonum
- Chlorzoxazonum [INN-Latin]
- Clorzoxazona
- Clorzoxazona [INN-Spanish]
- EINECS 202-403-9
- Escoflex
- Klorzoxazon
- Lorzone
- Mioran
- Miotran
- Myoflexin
- Myoflexine
- Neoflex
- NSC 26189
- Nyoflex
- Paraflex
- Parafon
- Parafon Forte
- Parafon Forte DSC
- Pathorysin
- Remofleks
- Solaxin
- Strifon
- Strifon Forte DSC
- UNII-H0DE420U8G
- USAF MA-10
Systematic Names
- 2(3H)-Benzoxazolone, 5-chloro-
- 2-Benzoxazolinone, 5-chloro-
- Chlorzoxazone
Registry Numbers
CAS Registry Number
- 95-25-0
FDA UNII
- H0DE420U8G
Other Registry Number
- 32850-84-3
System Generated Number
- 0000095250
Structure Descriptors
InChI
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)InChIKey
TZFWDZFKRBELIQ-UHFFFAOYSA-NSmiles
Oc1oc2ccc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
hamster | LD50 | intraperitoneal | 166mg/kg (166mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
hamster | LD50 | oral | 662mg/kg (662mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
mammal (species unspecified) | LD50 | intraperitoneal | 550mg/kg (550mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Chimica Therapeutica. Vol. 6, Pg. 65, 1971. |
man | TDLo | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA | American Journal of Emergency Medicine. Vol. 16, Pg. 393, 1998. |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. AD277-689, | |
mouse | LD50 | oral | 440mg/kg (440mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967. | |
mouse | LD50 | subcutaneous | 170mg/kg (170mg/kg) | BEHAVIORAL: ANTICONVULSANT | Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962. |
rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
rat | LD50 | oral | 763mg/kg (763mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 191.5 | deg C | EXP | |
log P (octanol-water) | 1.590 | (none) | EST | |
Atmospheric OH Rate Constant | 2.20E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.