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Substance Name: o-Toluidine
RN: 95-53-4
UNII: B635MZ0ZLU
InChIKey: RNVCVTLRINQCPJ-UHFFFAOYSA-N

Molecular Formula

  • C7-H9-N

Molecular Weight

  • 107.1551
 

Classification Codes

Classification Codes

  • Carcinogens
  • Human Data
  • Indicators and Reagents
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Known to be a Human Carcinogen.
  • Overall Carcinogenic Evaluation: Group 2A
  • Reportable Quantity (RQ) = 100 lb
  • TWA (2 ppm); skin; Confirmed animal carcinogen with unknown relevance to humans; BEI
  • TWA 5 ppm (22 mg/m3); skin

Names and Synonyms

Results Name

  • o-Toluidine

Name of Substance

  • 2-Aminotoluene
  • 2-Toluidine
  • o-Toluidine

Synonyms

  • 1-Amino-2-methylbenzene
  • 1-Methyl-2-aminobenzene
  • 2-Amino-1-methylbenzene
  • 2-Aminotoluene
  • 2-Methyl-1-aminobenzene
  • 2-Methylaniline
  • 2-Methylbenzamine
  • 2-Methylbenzenamine
  • 2-Toluidine
  • AI3-24383
  • Aniline, 2-methyl-
  • C.I. 37077
  • CCRIS 597
  • EC 202-429-0
  • EINECS 202-429-0
  • HSDB 2042
  • NSC 15348
  • o-Aminotoluene
  • o-Methylaniline
  • o-Methylbenzenamine
  • o-Toluidin
  • o-Toluidin [Czech]
  • o-Toluidine
  • o-Toluidyna
  • o-Toluidyna [Polish]
  • o-Tolylamine
  • ortho Toluidine
  • ortho-Toluidine
  • RCRA waste number U328
  • UNII-B635MZ0ZLU

Systematic Names

  • 2-Methylbenzenamine
  • Benzenamine, 2-methyl-
  • o-Toluidine

Superlist Names

  • Benzenamine, 2-methyl-
  • o-Toluidine
  • o-Toluidine, liquid or solid
  • o-Toluidine, liquid or solid [UN1708] [Poison]
  • RCRA waste no. U328
  • UN1708

Registry Numbers

CAS Registry Number

  • 95-53-4

FDA UNII

  • B635MZ0ZLU

Related Registry Number

  • 636-21-5 (hydrochloride)

System Generated Number

  • 0000095534

Structure Descriptors

InChI

1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3

InChIKey

RNVCVTLRINQCPJ-UHFFFAOYSA-N

Smiles

Cc1ccccc1N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 49, 1941.
frog LDLo oral 151mg/kg (151mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: COMA
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 49, 1941.
mammal (species unspecified) LD50 oral 1700mg/kg (1700mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
man TCLo inhalation 25mg/m3 (25mg/m3) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

KIDNEY, URETER, AND BLADDER: HEMATURIA
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(8), Pg. 7, 1970.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 oral 520mg/kg (520mg/kg) BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BLOOD: NORMOCYTIC ANEMIA
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.
rabbit LD50 oral 840mg/kg (840mg/kg) BLOOD: NORMOCYTIC ANEMIA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.
rabbit LD50 skin 3250uL/kg (3.25mL/kg)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LC50 inhalation 862ppm/4H (862ppm) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
National Technical Information Service. Vol. OTS0570956,
rat LD50 oral 670mg/kg (670mg/kg) BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS

BLOOD: NORMOCYTIC ANEMIA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.63E+01 deg C   EXP
Boiling Point 200.3 deg C   EXP
pKa Dissociation Constant 4.44 (none) 25 EXP
log P (octanol-water) 1.32 (none)   EXP
Water Solubility 1.66E+04 mg/L 25 EXP
Vapor Pressure 0.26 mm Hg 25 EXP
Henry's Law Constant 1.98E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.32E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.