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Substance Name: o-Toluidine
RN: 95-53-4
UNII: B635MZ0ZLU
InChIKey: RNVCVTLRINQCPJ-UHFFFAOYSA-N

Molecular Formula

  • C7-H9-N

Molecular Weight

  • 107.1551
 

Classification Codes

Classification Codes

  • Carcinogens
  • Human Data
  • Indicators and Reagents
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Known to be a Human Carcinogen.
  • Overall Carcinogenic Evaluation: Group 2A
  • Reportable Quantity (RQ) = 100 lb
  • TWA (2 ppm); skin; Confirmed animal carcinogen with unknown relevance to humans; BEI
  • TWA 5 ppm (22 mg/m3); skin

Names and Synonyms

Results Name

  • o-Toluidine

Name of Substance

  • 2-Aminotoluene
  • 2-Toluidine
  • o-Toluidine

Synonyms

  • 1-Amino-2-methylbenzene
  • 1-Methyl-2-aminobenzene
  • 2-Amino-1-methylbenzene
  • 2-Aminotoluene
  • 2-Methyl-1-aminobenzene
  • 2-Methylaniline
  • 2-Methylbenzamine
  • 2-Methylbenzenamine
  • 2-Toluidine
  • AI3-24383
  • Aniline, 2-methyl-
  • C.I. 37077
  • CCRIS 597
  • EC 202-429-0
  • EINECS 202-429-0
  • HSDB 2042
  • NSC 15348
  • o-Aminotoluene
  • o-Methylaniline
  • o-Methylbenzenamine
  • o-Toluidin
  • o-Toluidin [Czech]
  • o-Toluidine
  • o-Toluidyna
  • o-Toluidyna [Polish]
  • o-Tolylamine
  • ortho Toluidine
  • ortho-Toluidine
  • RCRA waste number U328
  • UNII-B635MZ0ZLU

Systematic Names

  • 2-Methylbenzenamine
  • Benzenamine, 2-methyl-
  • o-Toluidine

Superlist Names

  • Benzenamine, 2-methyl-
  • o-Toluidine
  • o-Toluidine, liquid or solid
  • o-Toluidine, liquid or solid [UN1708] [Poison]
  • RCRA waste no. U328
  • UN1708

Registry Numbers

CAS Registry Number

  • 95-53-4

FDA UNII

  • B635MZ0ZLU

Related Registry Number

  • 636-21-5 (hydrochloride)

System Generated Number

  • 0000095534

Structure Descriptors

InChI

1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3

InChIKey

RNVCVTLRINQCPJ-UHFFFAOYSA-N

Smiles

Cc1ccccc1N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BEHAVIORAL: COMA
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 49, 1941.
frog LDLo oral 151mg/kg (151mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 49, 1941.
mammal (species unspecified) LD50 oral 1700mg/kg (1700mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
man TCLo inhalation 25mg/m3 (25mg/m3) KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(8), Pg. 7, 1970.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 oral 520mg/kg (520mg/kg) BLOOD: NORMOCYTIC ANEMIA

BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.
rabbit LD50 oral 840mg/kg (840mg/kg) BLOOD: NORMOCYTIC ANEMIA

BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.
rabbit LD50 skin 3250uL/kg (3.25mL/kg)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LC50 inhalation 862ppm/4H (862ppm) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0570956,
rat LD50 oral 670mg/kg (670mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BLOOD: NORMOCYTIC ANEMIA

BLOOD: PIGMENTED OR NUCLEATED RED BLLOD CELLS
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 155, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.63E+01 deg C   EXP
Boiling Point 200.3 deg C   EXP
pKa Dissociation Constant 4.44 (none) 25 EXP
log P (octanol-water) 1.32 (none)   EXP
Water Solubility 1.66E+04 mg/L 25 EXP
Vapor Pressure 0.26 mm Hg 25 EXP
Henry's Law Constant 1.98E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.32E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.