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Substance Name: Gemcitabine [USAN:INN:BAN]
RN: 95058-81-4
UNII: B76N6SBZ8R
InChIKey: SDUQYLNIPVEERB-QPPQHZFASA-N
Note
- NCI: Gemcitabine hydrochloride is approved by the Food and Drug Administration (FDA) to be used by itself to treat pancreatic cancer that is advanced or has metastasized (spread to other parts of the body). It is used in patients who cannot be treated with surgery and have already been treated with other chemotherapy.[National Cancer Institute]
Molecular Formula
- C9-H11-F2-N3-O4
Molecular Weight
- 263.1989
Classification Codes
- Anti-Infective Agents
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic
- Antineoplastic Agents
- Antiviral Agents
- Enzyme Inhibitors
- Immunologic Factors
- Immunosuppressive Agents
- Noxae
- Radiation-Sensitizing Agents
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Names and Synonyms
Name of Substance
- Gemcitabine [USAN:INN:BAN]
Synonyms
- 2',2'-Difluorodeoxycytidine
- 2'-Deoxy-2',2'-difluorocytidine
- CCRIS 8984
- DDFC
- DFdC
- DFdCyd
- Folfugem
- Gamcitabine
- Gemcel
- Gemcitabina
- Gemcitabina [INN-Spanish]
- Gemcitabine
- Gemcitabinum
- Gemcitabinum [INN-Latin]
- GemLip
- HSDB 7567
- LY 188011
- LY188011
- NSC 613327
- UNII-B76N6SBZ8R
- Zefei
Systematic Name
- Cytidine, 2'-deoxy-2',2'-difluoro-
Registry Numbers
CAS Registry Number
- 95058-81-4
FDA UNII
- B76N6SBZ8R
Other Registry Number
- 1239668-67-7
Related Registry Numbers
- 103882-84-4
- 122111-03-9
System Generated Number
- 0095058814
Structure Descriptors
InChI
InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1InChIKey
SDUQYLNIPVEERB-QPPQHZFASA-NSmiles
NC1=NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | intravenous | 27mg/kg (27mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION | Journal of Cancer Research and Clinical Oncology. Vol. 125, Pg. 637, 1999. |