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Substance Name: Metalol hydrochloride [USAN]
RN: 955-48-6
InChIKey: OMGYZLAJZAMSKO-UHFFFAOYSA-N

Classification Code

  • Anti-Adrenergic (beta-Receptor)

Molecular Formula

  • C11-H18-N2-O3-S.Cl-H

Molecular Weight

  • 294.801
 
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Names and Synonyms

Name of Substance

  • Metalol hydrochloride [USAN]

Synonyms

  • 4'-(1-Hydroxy-2-(methylamino)propyl)methanesulfonanilide monohydrochloride
  • Metalol HCl
  • Metalol hydrochloride
  • Methanesulfonamide, N-(4-(1-hydroxy-2-(methylamino)propyl)phenyl)-, monohydrochloride

Systematic Names

  • Methanesulfonamide, N-(4-(1-hydroxy-2-(methylamino)propyl)phenyl)-, monohydrochloride
  • Methanesulfonanilide, 4'-(1-hydroxy-2-(methylamino)propyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 955-48-6

Other Registry Number

  • 5691-91-8

System Generated Number

  • 0000955486

Molecular Formulas

Molecular Formula

  • C11-H18-N2-O3-S.Cl-H

Molecular Formula Fragments

  • C11-H18-N2-O3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H18N2O3S.ClH/c1-8(12-2)11(14)9-4-6-10(7-5-9)13-17(3,15)16;/h4-8,11-14H,1-3H3;1H

InChIKey

OMGYZLAJZAMSKO-UHFFFAOYSA-N

Smiles

c1c(NS(C)(=O)=O)ccc(c1)[C@@H](O)[C@@H](C)NC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 485mg/kg (485mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
mouse LD50 intraperitoneal 785mg/kg (785mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
mouse LD50 oral > 6gm/kg (6000mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rabbit LD50 oral 1250mg/kg (1250mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rat LD50 intraperitoneal 850mg/kg (850mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rat LD50 oral > 6gm/kg (6000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.