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Substance Name: Phencyclidine hydrochloride [USAN]
RN: 956-90-1
UNII: V1JZQ7GDTX
InChIKey: BUAJNGPDPGKBGV-UHFFFAOYSA-N

Note

  • A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Molecular Formula

  • C17-H25-N.Cl-H

Molecular Weight

  • 279.852
 

Classification Codes

Classification Codes

  • Anesthetic
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Phencyclidine hydrochloride
  • Phencyclidine hydrochloride [USAN]

Synonyms

  • 1-(1-Phenylcyclohexyl)piperidine hydrochloride
  • C.I. 395
  • CI-395
  • CI395
  • CN-25,253-2
  • Elysion
  • GP-121
  • MCV 4158
  • NIH 9580
  • NSC-40902
  • PCP hydrochloride
  • Phencyclidine HCl
  • Phencyclidine hydrochloride
  • Sernyl
  • Sernyl hydrochloride
  • Sernylan
  • Trank
  • UNII-V1JZQ7GDTX

Systematic Name

  • Piperidine, 1-(1-phenylcyclohexyl)-, hydrochloride

Superlist Name

  • DEA No. 7471

Registry Numbers

CAS Registry Number

  • 956-90-1

FDA UNII

  • V1JZQ7GDTX

System Generated Number

  • 0000956901

Molecular Formulas

Molecular Formula

  • C17-H25-N.Cl-H

Molecular Formula Fragments

  • C17-H25-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H25N.ClH/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18;/h1,4-5,10-11H,2-3,6-9,12-15H2;1H

InChIKey

BUAJNGPDPGKBGV-UHFFFAOYSA-N

Smiles

C1(c2ccccc2)([NH+]2CCCCC2)CCCCC1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 5600ug/kg (5.6mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
dog LDLo intravenous 50mg/kg (50mg/kg) CARDIAC: CHANGE IN RATE

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology. Vol. 19, Pg. 11, 1981.
duck LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
human LDLo oral 14mg/kg (14mg/kg) BEHAVIORAL: COMA JAMA, Journal of the American Medical Association. Vol. 238, Pg. 515, 1977.
human TDLo intravenous 10ug/kg (0.01mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

PERIPHERAL NERVE AND SENSATION: PARESTHESIS
Canadian Psychiatric Association Journal. Vol. 6, Pg. 150, 1961.
human TDLo oral 71ug/kg (0.071mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
JAMA, Journal of the American Medical Association. Vol. 238, Pg. 515, 1977.
mouse LD50 intraperitoneal 59558ug/kg (59.558mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Substance and Alcohol Actions/Misuse. Vol. 2, Pg. 143, 1981.
mouse LD50 intravenous 16mg/kg (16mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Life Sciences. Vol. 31, Pg. 803, 1982.
mouse LD50 oral 77mg/kg (77mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 28, Pg. 713, 1976.
mouse LD50 subcutaneous 43mg/kg (43mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 496, 1981.
pigeon LD50 oral 237mg/kg (237mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat LD50 oral 135mg/kg (135mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Neurobehavioral Toxicology and Teratology. Vol. 3, Pg. 11, 1981.