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Substance Name: Nedaplatin [INN]
RN: 95734-82-0
UNII: 8UQ3W6JXAN
InChIKey: GYAVMUDJCHAASE-UHFFFAOYSA-M

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C2-H8-N2-O3-Pt

Molecular Weight

  • 303.176
 
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Names and Synonyms

Name of Substance

  • Nedaplatin
  • Nedaplatin [INN]

Synonyms

  • (Glycolato-O,O')diammineplatinum(II)
  • 254-S
  • CCRIS 4088
  • cis-Diammine (glycolato)platinum
  • cis-Diammine(glycolato)platinum(II)
  • Nedaplatin
  • NSC 375101D
  • UNII-8UQ3W6JXAN

Systematic Names

  • cis-Diammine(glycolato)platinum
  • cis-Diammine(glycolato-O(sup 1),O(sup 2))platinum
  • Platinum, diammine(hydroxy-kappaO)acetato(2-)-kappaO)-, (SP-4-3)-
  • Platinum, diammine(hydroxyacetato(2-)-O(sup 1),O(sup 2))-, (SP-4-3)-

Registry Numbers

CAS Registry Number

  • 95734-82-0

FDA UNII

  • 8UQ3W6JXAN

System Generated Number

  • 0095734820

Structure Descriptors

InChI

1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1

InChIKey

GYAVMUDJCHAASE-UHFFFAOYSA-M

Smiles

O1[Pt](OC(=O)C1)(N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 4mg/kg (4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
mouse LD50 intravenous 44100ug/kg (44.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat LDLo intravenous 20mg/kg (20mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Kiso to Rinsho. Clinical Report. Vol. 29, Pg. 3585, 1995.