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Substance Name: Sotalol hydrochloride [USAN:USP]
RN: 959-24-0
UNII: HEC37C70XX
InChIKey: VIDRYROWYFWGSY-UHFFFAOYSA-N

Note

  • An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.

Molecular Formula

  • C12-H20-N2-O3-S.Cl-H

Molecular Weight

  • 308.8279
 

Classification Codes

  • Anti-Adrenergic (beta-Receptor)
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sotalol hydrochloride [USAN:USP]

Synonyms

  • 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide monohydrochloride
  • 4-(2-Isopropylamino-1-hydroxyaethyl)methanesulfonailid hydrochlorid
  • 4-(2-Isopropylamino-1-hydroxyaethyl)methanesulfonailid hydrochlorid [German]
  • Berlex
  • Betapace
  • Betapace AF
  • EINECS 213-496-0
  • Isopropylaminohydroxyethylmethanesulfonanilide hydrochloride
  • Mead johnson 1999
  • Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, monohydrochloride
  • MJ 1999
  • N-Isopropyl-beta-(4-methanesulfonamidophenyl)ethanolamine hydrochloride
  • Sorine
  • Sotacor
  • Sotalex
  • Sotalol HCl
  • Sotalol hydrochloride
  • Sotylize
  • UNII-HEC37C70XX

Systematic Names

  • 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulphonanilide hydrochloride
  • Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, monohydrochloride
  • Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 959-24-0

FDA UNII

  • HEC37C70XX

Related Registry Number

  • 3930-20-9 (Parent)

System Generated Number

  • 0000959240

Molecular Formulas

Molecular Formula

  • C12-H20-N2-O3-S.Cl-H

Molecular Formula Fragments

  • C12-H20-N2-O3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

InChIKey

VIDRYROWYFWGSY-UHFFFAOYSA-N

Smiles

CC(C)NCC(c1ccc(cc1)NS(=O)(=O)C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 330mg/kg (330mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
human TDLo oral 64mg/kg/2W-I (64mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) British Medical Journal. Vol. 291, Pg. 544, 1985.
man LDLo oral 45714ug/kg (45.714mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Toxicology. Vol. 43, Pg. 221, 1980.
mouse LD50 intraperitoneal 670mg/kg (670mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
mouse LD50 oral 2600mg/kg (2600mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rabbit LD50 oral 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rat LD50 intraperitoneal 680mg/kg (680mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rat LD50 oral 3450mg/kg (3450mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 206.5-207 deg C   EXP
log P (octanol-water) 0.24 (none)   EXP
Water Solubility 1.37E+05 mg/L 25 EST
Vapor Pressure 3.37E-08 mm Hg 25 EST
Henry's Law Constant 2.66E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.03E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.