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Substance Name: gamma-Butyrolactone
RN: 96-48-0
UNII: OL659KIY4X
InChIKey: YEJRWHAVMIAJKC-UHFFFAOYSA-N

Note

  • One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.

Molecular Formula

  • C4-H6-O2

Molecular Weight

  • 86.0894
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Results Name

  • gamma-Butyrolactone

Name of Substance

  • 2(3H)-Furanone, dihydro-
  • 4-Butyrolactone
  • Butyrolactone
  • Dihydro-2(3H)-furanone

MeSH Heading

  • 4-Butyrolactone

Synonyms

  • 1,2-Butanolide
  • 1,4-Butanolide
  • 2(3H)-Furanone, dihydro-
  • 2-Oxolanone
  • 3-Hydroxybutyric acid lactone
  • 4-Butanolide
  • 4-Butyrolactone
  • 4-Deoxytetronic acid
  • 4-Hydroxybutanoic acid lactone
  • 4-Hydroxybutyric acid lactone
  • 6480
  • Agrisynth BLO
  • AI3-28121
  • BLO
  • BLON
  • Butanoic acid, 4-hydroxy-, gamma-lactone
  • Butyric acid lactone
  • Butyric acid, 4-hydroxy-, gamma-lactone
  • Butyrolactone
  • Butyryl lactone
  • Butyrylactone
  • C-1070
  • Caswell No. 132B
  • CCRIS 2924
  • Dihydro-2(3H)-furanone
  • Dihydro-2-furanone
  • EC 202-509-5
  • EINECS 202-509-5
  • EPA Pesticide Chemical Code 122303
  • FEMA No. 3291
  • gamma-6480
  • gamma-BL
  • gamma-Butyrolactone
  • gamma-Butyrolactone (natural)
  • gamma-Hydroxybutyric acid cyclic ester
  • gamma-Hydroxybutyric acid lactone
  • gamma-Hydroxybutyrolactone
  • GBL
  • HSDB 4290
  • NCI-C55878
  • No Go
  • NSC 4592
  • Tetrahydro-2-furanone
  • UNII-OL659KIY4X

Systematic Names

  • 2(3H)-Furanone, dihydro-
  • gamma-Butyrolactone

Superlist Names

  • 2(3H)-Furanone, dihydro-
  • Butyrolactone
  • gamma-Butyrolactone

Registry Numbers

CAS Registry Number

  • 96-48-0

FDA UNII

  • OL659KIY4X

Other Registry Number

  • 187997-16-6

System Generated Number

  • 0000096480

Structure Descriptors

InChI

1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2

InChIKey

YEJRWHAVMIAJKC-UHFFFAOYSA-N

Smiles

C1(=O)CCCO1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin > 5gm/kg (5000mg/kg)   GAF Material Safety Data Sheet.
mouse LD50 intraperitoneal 1100mg/kg (1100mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
mouse LD50 oral 1460mg/kg (1460mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 64(2), Pg. 3, 1999.
mouse LDLo parenteral 1600mg/kg (1600mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 687, 1955.
rabbit LDLo intravenous 500mg/kg (500mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
rat LC50 inhalation > 5100mg/m3/4H (5100mg/m3)   National Technical Information Service. Vol. OTS0534527,
rat LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.
rat LD50 oral 1540mg/kg (1540mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -4.33E+01 deg C   EXP
Boiling Point 204 deg C   EXP
log P (octanol-water) -0.64 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 0.45 mm Hg 25 EXP
Henry's Law Constant 5.27E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.31E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.