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Substance Name: Meropenem [INN]
RN: 96036-03-2
UNII: YOP6PX0BAO
InChIKey: DMJNNHOOLUXYBV-PQTSNVLCSA-N

Note

  • Broad-spectrum antimicrobial.

Molecular Formula

  • C17-H25-N3-O5-S

Molecular Weight

  • 383.4665
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Results Name

  • Meropenem [INN]

Name of Substance

  • Meropenem
  • Meropenem anhydrous
  • Meropenem [INN]

Synonyms

  • Antibiotic SM 7338
  • BRN 6940582
  • HSDB 8019
  • ICI 194660
  • Meropenem
  • Meropenemum
  • Meropenemum [INN-Latin]
  • Merrem
  • Merrem I.V.
  • SM 7338
  • UNII-YOP6PX0BAO

Systematic Names

  • 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)-
  • 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(S*,5S*),4-alpha,5-beta,6-beta(R*)))-

Registry Numbers

CAS Registry Number

  • 96036-03-2

FDA UNII

  • YOP6PX0BAO

System Generated Number

  • 0096036032

Structure Descriptors

InChI

InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1

InChIKey

DMJNNHOOLUXYBV-PQTSNVLCSA-N

Smiles

C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]3CN[C@@H](C3)C(=O)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Chemotherapy Vol. 40(Suppl,
mouse LD50 intravenous 2650mg/kg (2650mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Chemotherapy Vol. 40(Suppl,
mouse LD50 oral > 5gm/kg (5000mg/kg)   Chemotherapy Vol. 40(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Chemotherapy Vol. 40(Suppl,
rat LD50 intravenous 2850mg/kg (2850mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Chemotherapy Vol. 40(Suppl,
rat LD50 oral > 5gm/kg (5000mg/kg)   Chemotherapy Vol. 40(Suppl,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Chemotherapy Vol. 40(Suppl,