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Substance Name: Moxisylyte hydrochloride [JAN]
RN: 964-52-3
UNII: WK2KZM9V6X
InChIKey: IPWGSXZCDPTDEH-UHFFFAOYSA-N

Note

  • An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)

Molecular Formula

  • C16-H25-N-O3.Cl-H

Molecular Weight

  • 315.838
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Moxisylyte hydrochloride
  • Moxisylyte hydrochloride [JAN]

Synonyms

  • (2-(4-Acetoxy-2-isopropyl-5-methylphenoxy)ethyl)dimethylamine hydrochloride
  • 5-(2-(N,N-Dimethylamino)ethoxy)carvacrol acetate hydrochloride
  • Arlitene
  • Carlytene
  • Chlorhydrate de acetoxy-thymoxy-ethyl-dimethylamine
  • Chlorhydrate de acetoxy-thymoxy-ethyl-dimethylamine [French]
  • EINECS 213-519-4
  • Enfrental
  • Limatene
  • M-101
  • Moxilite
  • Moxisylyte HCl
  • Moxisylyte hydrochloride
  • NSC 170448
  • Opilon
  • Thymoxamine hydrochloride
  • UNII-WK2KZM9V6X
  • Vasoklin
  • WV 365

Systematic Names

  • Carvacrol, 5-(2-(dimethylamino)ethoxy)-, acetate (ester), hydrochloride (8CI)
  • Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-, acetate, hydrochloride
  • Moxisylyte hydrochloride
  • Phenol, 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)-, acetate (ester), hydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 964-52-3

FDA UNII

  • WK2KZM9V6X

System Generated Number

  • 0000964523

Molecular Formulas

Molecular Formula

  • C16-H25-N-O3.Cl-H

Molecular Formula Fragments

  • C16-H25-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H25NO3.ClH/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6;/h9-11H,7-8H2,1-6H3;1H

InChIKey

IPWGSXZCDPTDEH-UHFFFAOYSA-N

Smiles

c1(c(cc(C)c(c1)OC(C)=O)OCC[NH+](C)C)C(C)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
cat LDLo oral 375mg/kg (375mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
dog LD50 intravenous 54500ug/kg (54.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
dog LDLo oral 700mg/kg (700mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
monkey LDLo intravenous 40mg/kg (40mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
monkey LDLo oral 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
mouse LD50 intraperitoneal 81mg/kg (81mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
mouse LD50 intravenous 28mg/kg (28mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
mouse LD50 oral 225mg/kg (225mg/kg)   United States Patent Document. Vol. #4818772,
mouse LD50 subcutaneous 152mg/kg (152mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
rabbit LD50 intravenous 58600ug/kg (58.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
rabbit LDLo oral > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 147, 1982.
rat LD50 intraperitoneal 96mg/kg (96mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
rat LD50 intravenous 32mg/kg (32mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1147, 1982.
rat LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: COMA
Therapie. Vol. 26, Pg. 775, 1971.
rat LD50 subcutaneous 190mg/kg (190mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS
Therapie. Vol. 26, Pg. 775, 1971.