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Substance Name: Palonidipine hydrochloride
RN: 96515-74-1
InChIKey: OQHXRVQARZHYGQ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C29-H34-F-N3-O6.Cl-H

Molecular Weight

  • 576.0615
 
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Names and Synonyms

Results Name

  • Palonidipine hydrochloride

Name of Substance

  • TC 81

Synonyms

  • CCRIS 8938
  • Palonidipine HCl
  • Palonidipine hydrochloride
  • TC-81

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-, 2,2-dimethyl-3-(methyl(phenylmethyl)amino)propyl methyl ester, monohydrochloride
  • 3,5-Pyridinedicarboxylic acid, 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-, 2,2-dimethyl-3-(methyl(phenylmethyl)amino)propyl methyl ester, monohydrochloride

Registry Numbers

CAS Registry Number

  • 96515-74-1

System Generated Number

  • 0096515741

Molecular Formulas

Molecular Formula

  • C29-H34-F-N3-O6.Cl-H

Molecular Formula Fragments

  • C29-H34-F-N3-O6
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C29H34FN3O6.ClH/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20;/h7-14,26,31H,15-17H2,1-6H3;1H

InChIKey

OQHXRVQARZHYGQ-UHFFFAOYSA-N

Smiles

CC1=C(C(C(=C(N1)C)C(=O)OCC(C)(C)CN(C)Cc2ccccc2)c3cc(ccc3F)[N+](=O)[O-])C(=O)OC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 25mg/kg (25mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
mouse LD50 intraperitoneal 23830ug/kg (23.83mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
mouse LD50 intraperitoneal 23830ug/kg (23.83mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
mouse LD50 oral 52690ug/kg (52.69mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
mouse LD50 subcutaneous 233mg/kg (233mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
rat LD50 intraperitoneal 22810ug/kg (22.81mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
rat LD50 intraperitoneal 22810ug/kg (22.81mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
rat LD50 oral 30540ug/kg (30.54mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
rat LD50 subcutaneous 55310ug/kg (55.31mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.
rat LD50 subcutaneous 55310ug/kg (55.31mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 2223, 1992.