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Substance Name: Acetohexamide [USAN:USP:INN:BAN:JAN]
RN: 968-81-0
UNII: QGC8W08I6I
InChIKey: VGZSUPCWNCWDAN-UHFFFAOYSA-N

Note

  • A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.

Molecular Formula

  • C15-H20-N2-O4-S

Molecular Weight

  • 324.399
 

Classification Codes

  • Antidiabetic
  • Drug / Therapeutic Agent
  • Human Data
  • Hypoglycemic Agents
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Acetohexamide
  • Acetohexamide [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Acetohexamide

Synonyms

  • 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea
  • 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea
  • 33006
  • 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide
  • Acetohexamid
  • Acetohexamida
  • Acetohexamida [INN-Spanish]
  • Acetohexamide
  • Acetohexamidum
  • Acetohexamidum [INN-Latin]
  • Benzenesulfonamide, 4-acetyl-N-((cyclohexylamino)carbonyl)-
  • BRN 2225115
  • CCRIS 4
  • Dimelin
  • Dimelor
  • Dymelor
  • EINECS 213-530-4
  • Gamadiabet
  • HSDB 3280
  • Hypoglicil
  • Metaglucina
  • Minoral
  • N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea
  • NCI-C03247
  • Ordimel
  • Tsiklamid
  • U 14812
  • U-14812
  • UNII-QGC8W08I6I

Systematic Names

  • Acetohexamide
  • Benzenesulfonamide, 4-acetyl-N-((cyclohexylamino)carbonyl)-
  • Urea, 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-

Superlist Name

  • Acetohexamide

Registry Numbers

CAS Registry Number

  • 968-81-0

FDA UNII

  • QGC8W08I6I

Other Registry Number

  • 8054-32-8

System Generated Number

  • 0000968810

Structure Descriptors

InChI

1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChIKey

VGZSUPCWNCWDAN-UHFFFAOYSA-N

Smiles

S(=O)(=O)(c1ccc(cc1)C(=O)C)NC(=O)NC1CCCCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 18, 1982.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 34, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.44 (none)   EXP
Water Solubility 3430 mg/L 37 EXP
Vapor Pressure 3.39E-10 mm Hg 25 EST
Henry's Law Constant 3.25E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.16E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.