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Substance Name: Opromazine
RN: 969-99-3
UNII: 016U10PN9N
InChIKey: QEPPAOXKZOTMPM-UHFFFAOYSA-N

Molecular Formula

  • C17-H19-Cl-N2-O-S

Molecular Weight

  • 334.8691
 
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Names and Synonyms

Name of Substance

  • Opromazine

Synonyms

  • 10-(gamma-Dimethylaminopropyl)-3-chlorophenothiazine 9-oxide
  • 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine-5-oxide
  • 4-27-00-01312 (Beilstein Handbook Reference)
  • 5-Oxychlorpromazine
  • 5293 RP
  • Ba 2835
  • BRN 0307255
  • Chloropromazine sulfoxide
  • Chlorpromazine sulfoxide
  • Chlorpromazine sulphoxide
  • Chlorpromazine-S-oxide
  • Chlorpromazine-S-oxyd
  • CPZ-O
  • NP 956
  • NSC 170990
  • Opromazin
  • Opromazine
  • Oxychlorpromazine
  • Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, oxide
  • Secotil
  • Sulfoxide of chlorpromazine
  • Transedon
  • UNII-016U10PN9N

Systematic Names

  • 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, 5-oxide (9CI)
  • Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, 5-oxide (8CI)
  • Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide

Registry Numbers

CAS Registry Number

  • 969-99-3

FDA UNII

  • 016U10PN9N

System Generated Number

  • 0000969993

Structure Descriptors

InChI

1S/C17H19ClN2OS/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)22(21)17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

InChIKey

QEPPAOXKZOTMPM-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2S(=O)c3c1cc(cc3)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 163mg/kg (163mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 328, 1956.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 71S, 1957.
mouse LD50 subcutaneous 102mg/kg (102mg/kg)   Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 8, Pg. 50, 1957.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 115 deg C   EXP
log P (octanol-water) 2.32 (none)   EXP
Water Solubility 63.1 mg/L 25 EST
Vapor Pressure 9.75E-09 mm Hg 25 EST
Henry's Law Constant 2.33E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.05E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.