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Substance Name: Acetarsone [INN:NF]
RN: 97-44-9
UNII: 806529YU1N
InChIKey: ODFJOVXVLFUVNQ-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Molecular Formula

  • C8-H10-As-N-O5

Molecular Weight

  • 275.091
 
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Names and Synonyms

Name of Substance

  • Acetarsone [INN:NF]

Synonyms

  • 190 F
  • 3-16-00-01132 (Beilstein Handbook Reference)
  • 3-Acetamido-4-hydroxy-phenylarsonic acid
  • 3-Acetamido-4-hydroxybenzenearsonic acid
  • 3-Acetamido-4-hydroxyphenylarsonsaeure
  • 3-Acetylamino-4-hydroxyphenylarsonic acid
  • Acetamino-hydroxyphenyl-arsonsaeure
  • Acetarsol
  • Acetarsol [INN:BAN]
  • Acetarsolo
  • Acetarsolo [DCIT]
  • Acetarsolum
  • Acetarsolum [INN-Latin]
  • Acetarsone
  • Acetphenarsine
  • AI3-16141
  • Amarsan
  • Amoebal
  • Arsaphen
  • Arsonine
  • BRN 2941984
  • Chrlich 594
  • Devegan
  • Disparicida
  • Dynarsan
  • Ehrlich 594
  • EINECS 202-582-3
  • F 190
  • Fourneau 190
  • Ginarsol
  • Goyl
  • Gynoplix
  • Kharophen
  • Kubarsol
  • Limarsol
  • Malagride
  • Mexyl
  • Monargan
  • N-Acetyl-4-hydroxy-m-arsanilic acid
  • Nilacid
  • NSC 13160
  • Oralcid
  • Orarsan
  • Osarsal
  • Osarsol
  • Osarsole
  • Osarsolum
  • Osvarsan
  • Osvarson
  • Pallicid
  • Paroxyl
  • Sanogyl
  • Spirocid
  • Spirozid
  • Stovarsal
  • Stovarsol
  • Stovarsolan
  • SVC
  • UNII-806529YU1N
  • Vagisept
  • Vagoflor

Systematic Names

  • Acetarsol
  • Arsonic acid, (3-(acetylamino)-4-hydroxyphenyl)- (9CI)
  • m-Arsanilic acid, N-acetyl-4-hydroxy-
  • N-Acetyl-4-hydroxy-m-arsanilic acid

Registry Numbers

CAS Registry Number

  • 97-44-9

FDA UNII

  • 806529YU1N

Related Registry Numbers

  • 55588-51-7 (unspecified hydrochloride salt)
  • 5892-48-8 (mono-hydrochloride salt)
  • 64046-96-4 (calcium salt)
  • 64046-96-4 (unspecified calcium salt)

System Generated Number

  • 0000097449

Structure Descriptors

InChI

1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)

InChIKey

ODFJOVXVLFUVNQ-UHFFFAOYSA-N

Smiles

c1(cc(ccc1O)[As](O)(O)=O)NC(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 150mg/kg (150mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 27, Pg. 267, 1930.
cat LDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Proceedings of the Society for Experimental Biology and Medicine. Vol. 27, Pg. 267, 1930.
man TDLo oral 89mg/kg/9D (89mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

ENDOCRINE: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of the Medical Sciences. Vol. 174, Pg. 819, 1927.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03309,
mouse LD50 oral 4mg/kg (4mg/kg)   Compilation of LD50 Values of New Drugs.
rabbit LDLo intravenous 120mg/kg (120mg/kg)   Archives of Dermatology and Syphilology. Vol. 25, Pg. 799, 1932.
rabbit LDLo oral 125mg/kg (125mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 27, Pg. 267, 1930.
rabbit LDLo oral 125mg/kg (125mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Proceedings of the Society for Experimental Biology and Medicine. Vol. 27, Pg. 267, 1930.
rat LDLo intravenous 300mg/kg (300mg/kg)   Archives of Dermatology and Syphilology. Vol. 25, Pg. 799, 1932.
rat LDLo oral 1200mg/kg (1200mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 3, Pg. 44, 1948.
women LDLo intravaginal 155mg/kg/2D-I (155mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING
British Medical Journal. Vol. 1, Pg. 1282, 1961.
women LDLo intravaginal 1576mg/kg/2D- (1576mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
British Medical Journal. Vol. 2, Pg. 242, 1960.
women TDLo oral 86mg/kg/8D (86mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Journal of the Medical Sciences. Vol. 174, Pg. 819, 1927.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.340 (none)   EST
Atmospheric OH Rate Constant 1.80E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.