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Substance Name: Staurosporine aglycone
RN: 97161-97-2
InChIKey: KOZFSFOOLUUIGY-UHFFFAOYSA-N

Note

  • Metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor.

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme Inhibitors

Molecular Formula

  • C27-H21-N3-O5

Molecular Weight

  • 467.4789
 
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Names and Synonyms

Name of Substance

  • Staurosporine aglycone

Synonym

  • K-252a

Systematic Name

  • K 252

Registry Numbers

CAS Registry Number

  • 97161-97-2

System Generated Number

  • 0097161972

Structure Descriptors

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)

InChIKey

KOZFSFOOLUUIGY-UHFFFAOYSA-N

Smiles

COC(=O)C1(O)CC2OC1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal > 100gm/kg (100000mg/kg)   Journal of Antibiotics. Vol. 39, Pg. 1059, 1986.