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Substance Name: Diphenidol [USAN]
RN: 972-02-1
UNII: NQO8R319LY
InChIKey: OGAKLTJNUQRZJU-UHFFFAOYSA-N

Note

  • Shows anti-arrhythmic activity.

Molecular Formula

  • C21-H27-N-O

Molecular Weight

  • 309.45
 

Classification Codes

  • Anti-Emetic
  • Antiemetics
  • Autonomic Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Human Data
  • Peripheral Nervous System Agents

Names and Synonyms

Name of Substance

  • Difenidol [INN]
  • Diphenidol
  • Diphenidol [USAN]

Synonyms

  • 1-Piperidinebutanol, alpha,alpha-diphenyl-
  • 5-20-02-00249 (Beilstein Handbook Reference)
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Avomol
  • Benzhydrol, alpha-(3-piperidinopropyl)-
  • BRN 0265884
  • Cephadol
  • Difenidol
  • Difenidolo
  • Difenidolo [DCIT]
  • Difenidolum
  • Difenidolum [INN-Latin]
  • Diphenidol
  • Diphenyl(3-(1-piperidyl)propyl)carbinol
  • EINECS 213-540-9
  • HSDB 3316
  • Nometic
  • SK&F 478
  • SKF 478
  • UNII-NQO8R319LY
  • Vontrol

Systematic Names

  • 1-Piperidinebutanol, alpha,alpha-diphenyl-
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Difenidol

Registry Numbers

CAS Registry Number

  • 972-02-1

FDA UNII

  • NQO8R319LY

Related Registry Number

  • 3254-89-5 (hydrochloride)

System Generated Number

  • 0000972021

Structure Descriptors

InChI

1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2

InChIKey

OGAKLTJNUQRZJU-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)(CCCN1CCCCC1)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 15mg/kg (15mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 33, 1998.
child TDLo oral 11700ug/kg (11.7mg/kg) BEHAVIORAL: COMA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 33, 1998.
mouse LD50 intraperitoneal 103mg/kg (103mg/kg)   Liebigs Annalen der Chemie. Vol. (10), Pg. 1554, 1979.
mouse LD50 intravenous 32mg/kg (32mg/kg)   Medicina et Pharmacologia Experimentalis. Vol. 13, Pg. 325, 1965.
mouse LD50 oral 450mg/kg (450mg/kg)   Pharmacologist. Vol. 5, Pg. 265, 1963.
rat LD50 oral 815mg/kg (815mg/kg)   Pharmacologist. Vol. 5, Pg. 265, 1963.
rat LD50 subcutaneous 304mg/kg (304mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 104.5 deg C   EXP
log P (octanol-water) 4.710 (none)   EST
Atmospheric OH Rate Constant 1.17E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.