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Substance Name: Topiramate [USAN:USP:INN:BAN]
RN: 97240-79-4
UNII: 0H73WJJ391
InChIKey: KJADKKWYZYXHBB-XBWDGYHZSA-N
Note
- A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.
Molecular Formula
- C12-H21-N-O8-S
Molecular Weight
- 339.3629
Classification Codes
- Anti-Obesity Agents
- Anticonvulsant
- Anticonvulsants
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Hypoglycemic Agents
- Neuroprotective Agents
- Protective Agents
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Names and Synonyms
Name of Substance
- Topiramate
- Topiramate [USAN:USP:INN:BAN]
MeSH Heading
- Topiramate
Synonyms
- 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
- 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
- BRN 5988957
- Epitomax
- HSDB 7531
- McN 4853
- McN-4853
- NSC 759251
- Qudexy XR
- RWJ-17021
- RWJ-17021-000
- Tipiramate
- Tipiramate [French]
- Tipiramato
- Tipiramato [Spanish]
- Topamax
- Topamax Sprinkle
- Topax
- Topiragen
- Topiramate
- Topiramato
- Topiramato [INN-Spanish]
- Topiramatum
- Topiramatum [INN-Latin]
- Topiramatum [Latin]
- Trokendi XR
- UNII-0H73WJJ391
- USL 255
Systematic Name
- beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
Registry Numbers
CAS Registry Number
- 97240-79-4
FDA UNII
- 0H73WJJ391
System Generated Number
- 0097240794
Structure Descriptors
InChI
InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1InChIKey
KJADKKWYZYXHBB-XBWDGYHZSA-NSmiles
CC1(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD50 | intraperitoneal | > 1500mg/kg (1500mg/kg) | Drugs of the Future. Vol. 14, Pg. 342, 1989. |