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Substance Name: Topiramate [USAN:USP:INN:BAN]
RN: 97240-79-4
UNII: 0H73WJJ391
InChIKey: KJADKKWYZYXHBB-XBWDGYHZSA-N

Note

  • A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.

Molecular Formula

  • C12-H21-N-O8-S

Molecular Weight

  • 339.3629
 

Classification Codes

  • Anti-Obesity Agents
  • Anticonvulsant
  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Hypoglycemic Agents
  • Neuroprotective Agents
  • Protective Agents

Names and Synonyms

Name of Substance

  • Topiramate
  • Topiramate [USAN:USP:INN:BAN]

MeSH Heading

  • Topiramate

Synonyms

  • 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
  • 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
  • BRN 5988957
  • Epitomax
  • HSDB 7531
  • McN 4853
  • McN-4853
  • Qudexy XR
  • RWJ-17021
  • RWJ-17021-000
  • Tipiramate
  • Tipiramate [French]
  • Tipiramato
  • Tipiramato [Spanish]
  • Topamax
  • Topamax Sprinkle
  • Topax
  • Topiragen
  • Topiramate
  • Topiramato
  • Topiramato [INN-Spanish]
  • Topiramatum
  • Topiramatum [INN-Latin]
  • Topiramatum [Latin]
  • Trokendi XR
  • UNII-0H73WJJ391
  • USL 255

Systematic Name

  • beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate

Registry Numbers

CAS Registry Number

  • 97240-79-4

FDA UNII

  • 0H73WJJ391

System Generated Number

  • 0097240794

Structure Descriptors

InChI

InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1

InChIKey

KJADKKWYZYXHBB-XBWDGYHZSA-N

Smiles

CC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal > 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 14, Pg. 342, 1989.